Active Flt3 dimer binds Grb2

Stable Identifier
R-MMU-9604768
Type
Reaction [binding]
Species
Mus musculus
Compartment
General
SVG |   | PPTX  | SBGN
Active Flt3 dimer binds Grb2

Feline McDonough Sarcoma-like tyrosine kinase (Flt3) is a member of the class III tyrosine kinase receptor family. Ligand binding induces conformational changes in the Flt3 receptor, which facilitates its dimerization and autophosphorylation. Once fully active, Flt3 receptors can associate with growth factor receptor-bound protein 2 (Grb2) and facilitate downstream regulation of effectors (Masson et al. 2009, Chonabayashi et al. 2013).

Literature References
PubMed ID Title Journal Year
23168613 Direct binding of Grb2 has an important role in the development of myeloproliferative disease induced by ETV6/FLT3

Chonabayashi, K, Hishizawa, M, Kawamata, S, Nagai, Y, Ohno, T, Ishikawa, T, Uchiyama, T, Takaori-Kondo, A

Leukemia 2013
19438505 A role of Gab2 association in Flt3 ITD mediated Stat5 phosphorylation and cell survival

Masson, K, Liu, T, Khan, R, Sun, J, Rönnstrand, L

Br. J. Haematol. 2009
Participants
Orthologous Events
Authored
Reviewed
Created