Notch1 and Notch4 gene transcription is inhibited by Sirt6

Stable Identifier
R-MMU-9604833
Type
Reaction [omitted]
Species
Mus musculus
Compartment
General
SVG |   | PPTX  | SBGN
Notch1 and Notch4 gene transcription is inhibited by Sirt6

Mouse Sirt6 mediates deacetylation of lysine residue 10 of H3 histones (removal of H3K9Ac epigenetic mark) at promoters of mouse Notch1 and Notch4 genes and inhibits their transcription. Targeted knockout of Sirt6 gene in mouse podocytes exacerbates podocyte injury in mouse models of diabetic nephropathy and adriamycin-induced nephropathy, which can be rescued by inhibition of Notch signaling (Liu et al. 2017).

Literature References
PubMed ID Title Journal Year
28871079 Sirt6 deficiency exacerbates podocyte injury and proteinuria through targeting Notch signaling

Liu, M, Liang, K, Zhen, J, Zhou, M, Wang, X, Wang, Z, Wei, X, Zhang, Y, Sun, Y, Zhou, Z, Su, H, Zhang, C, Li, N, Gao, C, Peng, J, Yi, F

Nat Commun 2017
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