Sirt6 deacetylates histones at Notch1 and Notch4 gene promoters

Stable Identifier
R-MMU-9604841
Type
Reaction [transition]
Species
Mus musculus
Compartment
General
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Sirt6 deacetylates histones at Notch1 and Notch4 gene promoters

Mouse Sirt6 deacetylates H3 histones on lysine residue 10 (removing the H3K9Ac epigenetic mark) at promoters of mouse Notch1 and Notch4 genes (Liu et al. 2017).

Literature References
PubMed ID Title Journal Year
28871079 Sirt6 deficiency exacerbates podocyte injury and proteinuria through targeting Notch signaling

Liu, M, Liang, K, Zhen, J, Zhou, M, Wang, X, Wang, Z, Wei, X, Zhang, Y, Sun, Y, Zhou, Z, Su, H, Zhang, C, Li, N, Gao, C, Peng, J, Yi, F

Nat Commun 2017
Participants
Catalyst Activity
Catalyst Activity
Title
NAD-dependent histone deacetylase activity (H3-K9 specific) of Sirt6:Nucleosome(H3K9ac):Notch1,Notch4 gene [nucleoplasm]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created
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