Active Flt3 binds Fyn

Stable Identifier
R-MMU-9605258
Type
Reaction [binding]
Species
Mus musculus
Compartment
cytosol, plasma membrane
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Active Flt3 binds Fyn
Feline McDonough Sarcoma-like tyrosine kinase (Flt3) is a member of the class III tyrosine kinase receptor family. Ligand binding induces conformational changes in Flt3 receptor, which facilitates its dimerization and autophosphorylation. Subsequently, tyrosine-protein kinase Fyn (Fyn) associates with the phosphorylated residues of fully active Flt3 (Y591, Y599 and pY955) through its SH2 domain (Dosil et al. 1993, Chougule et al. 2016).
Literature References
PubMed ID Title Journal Year
7692230 Mitogenic signalling and substrate specificity of the Flk2/Flt3 receptor tyrosine kinase in fibroblasts and interleukin 3-dependent hematopoietic cells

Wang, S, Dosil, M, Lemischka, IR

Mol. Cell. Biol. 1993
26848862 FYN expression potentiates FLT3-ITD induced STAT5 signaling in acute myeloid leukemia

Kazi, JU, Chougule, RA, Rönnstrand, L

Oncotarget 2016
Participants
Input
Output
Orthologous Events
Active FLT3 binds FYN (Homo sapiens)
Authored
Varusai, TM  (2019-01-14)
Reviewed
Traer, E  (2019-05-03)
Joshi, S  (2019-05-21)
Created
Varusai, TM  (2018-04-09)
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