Active Flt3:Grb2 binds Gab2

Stable Identifier
R-MMU-9606623
Type
Reaction [binding]
Species
Mus musculus
Compartment
General
SVG |   | PPTX  | SBGN
Active Flt3:Grb2 binds Gab2

Feline McDonough Sarcoma-like tyrosine kinase (Flt3) is a member of the class III tyrosine kinase receptor family. Ligand binding induces conformational changes in the Flt3 receptor, which facilitates its dimerization and autophosphorylation. Once fully active, Flt3 receptors can associate with growth factor receptor-bound protein 2 (Grb2). Subsequently, Grb2-associated-binding protein 2 (Gab2) binds Grb2 (Zhang et al. 2000, Masson et al. 2009, Chonabayashi et al. 2013).

Literature References
PubMed ID Title Journal Year
11027663 Flt3 ligand induces tyrosine phosphorylation of gab1 and gab2 and their association with shp-2, grb2, and PI3 kinase

Zhang, S, Broxmeyer, HE

Biochem. Biophys. Res. Commun. 2000
19438505 A role of Gab2 association in Flt3 ITD mediated Stat5 phosphorylation and cell survival

Masson, K, Liu, T, Khan, R, Sun, J, Rönnstrand, L

Br. J. Haematol. 2009
23168613 Direct binding of Grb2 has an important role in the development of myeloproliferative disease induced by ETV6/FLT3

Chonabayashi, K, Hishizawa, M, Kawamata, S, Nagai, Y, Ohno, T, Ishikawa, T, Uchiyama, T, Takaori-Kondo, A

Leukemia 2013
Participants
Orthologous Events
Authored
Reviewed
Created