Irak1 gene expression is inhibited by Mecp2

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R-MMU-9615830
Type
Reaction [omitted]
Species
Mus musculus
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General
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Irak1 gene expression is inhibited by Mecp2

In mouse cortical neurons, Mecp2 represses Irak1 gene transcription. Irak1, a serine/threonine protein kinase that activates Nfkb-mediated transcription, is upregulated in the cortex of Mecp2 null mice. Some of the Rett syndorome features, such as reduced dendritic complexity and decreased life span, can be ameliorated by attenuation of Nfkb signaling (Kishi et al. 2016).

Literature References
PubMed ID Title Journal Year
26821816 Reduction of aberrant NF-κB signalling ameliorates Rett syndrome phenotypes in Mecp2-null mice

Kishi, N, MacDonald, JL, Ye, J, Molyneaux, BJ, Azim, E, Macklis, JD

Nat Commun 2016
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