Runx1, Spi1, Gata2, Tal1, Fli1, Myb, and Cebpa bind the promoter of the Cebpa gene

Stable Identifier
R-MMU-9616215
Type
Reaction
Species
Mus musculus
Compartment
General
SVG |   | PPTX  | SBGN
Runx1, Spi1, Gata2, Tal1, Fli1, Myb, and Cebpa bind the promoter of the Cebpa gene

The evolutionarily conserved upstream enhancer of the Cebpa gene binds Runx1 (Guo et al. 2012), Spi1 (PU.1), Gata2, Tal1 (Scl), Fli1, Myb, and Cebpa (Lane et al. 1996) in myeloid progenitor cells (Wilson et al. 2010, Guo et al. 2014, Cooper et al. 2015). Cebpa, Runx1, Gata2, SCL, SPI1, and Fli1 concomitantly bind the Cebpa promoter (Wilson et al. 2010, Cooper et al.2015). Runx1 appears to be required to produce sufficient Cebpa for granulopoiesis, as Cebpa:Cebpa homodimers favor granulopoiesis while monopoiesis is favored by a reduction in Runx1 (Guo et al. 2012) and AP-1:Cebpa heterodimers (Cooper et al. 2015).

Literature References
PubMed ID Title Journal Year
22451420 Runx1 deletion or dominant inhibition reduces Cebpa transcription via conserved promoter and distal enhancer sites to favor monopoiesis over granulopoiesis

Guo, H, Ma, O, Speck, NA, Friedman, AD

Blood 2012
25938608 The +37 kb Cebpa Enhancer Is Critical for Cebpa Myeloid Gene Expression and Contains Functional Sites that Bind SCL, GATA2, C/EBPα, PU.1, and Additional Ets Factors

Cooper, S, Guo, H, Friedman, AD

PLoS ONE 2015
8680485 Control of adipocyte differentiation by CCAAT/enhancer binding protein alpha (C/EBP alpha)

Lane, MD, Lin, FT, MacDougald, OA, Vasseur-Cognet, M

Int. J. Obes. Relat. Metab. Disord. 1996
20887958 Combinatorial transcriptional control in blood stem/progenitor cells: genome-wide analysis of ten major transcriptional regulators

Wilson, NK, Foster, SD, Wang, X, Knezevic, K, Schütte, J, Kaimakis, P, Chilarska, PM, Kinston, S, Ouwehand, WH, Dzierzak, E, Pimanda, JE, de Bruijn, MF, Göttgens, B

Cell Stem Cell 2010
24868087 The Cebpa +37-kb enhancer directs transgene expression to myeloid progenitors and to long-term hematopoietic stem cells

Guo, H, Ma, O, Friedman, AD

J. Leukoc. Biol. 2014
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