G6pc gene expression is stimulated by Foxo6

Stable Identifier
R-MMU-9623272
Type
Reaction [omitted]
Species
Mus musculus
Compartment
nucleoplasm, endoplasmic reticulum membrane
ReviewStatus
5/5
General
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PNG
Low
Medium
High
 | PPTX  | SBGN
G6pc gene expression is stimulated by Foxo6
In mouse liver cells, Foxo6 directly stimulates transcription of the G6pc gene, encoding glucose-6-phosphatase (Kim et al. 2011). G6pc gene transcription is also directly stimulated by the complex of Foxo1 and Pparg1ca (Puigserver et al. 2003).
Literature References
PubMed ID Title Journal Year
12754525 Insulin-regulated hepatic gluconeogenesis through FOXO1-PGC-1alpha interaction

Walkey, CJ, Spiegelman, BM, Dong, H, Puigserver, P, Accili, D, Oriente, F, Rhee, J, Altomonte, J, Yoon, JC, Donovan, J, Kitamura, Y

Nature 2003
21940782 FoxO6 integrates insulin signaling with gluconeogenesis in the liver

Dong, HH, Lee, S, Giannoukakis, N, Strom, S, Gramignoli, R, Fan, Y, Perdomo, G, Phillips, BE, Kim, DH, Slusher, S, Zhang, T, Ringquist, S

Diabetes 2011
Participants
Input
Output
This event is regulated
Positively by
Regulator
Foxo1:Ppargc1a:G6pc gene [nucleoplasm] (Mus musculus)
Active Unit
Foxo1:Ppargc1a [nucleoplasm]
Regulator
Foxo6:G6pc gene [nucleoplasm] (Mus musculus)
Active Unit
Foxo6 [nucleoplasm]
Orthologous Events
G6PC gene expression is stimulated by FOXO1,FOXO3,FOXO4,FOXO6 (Homo sapiens)
Authored
Orlic-Milacic, M  (2018-10-11)
Reviewed
Bertaggia, E  (2018-10-26)
Donlon, T  (2018-10-17)
Created
Orlic-Milacic, M  (2018-10-03)
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