Cebpa mRNA is translated to yield Cebpa protein

Stable Identifier
R-MMU-9626284
Type
Reaction [omitted]
Species
Mus musculus
Compartment
cytosol, nucleoplasm
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Cebpa mRNA is translated to yield Cebpa protein
In the cytosol, 80S ribosomes translate the Cebpa mRNA to yield Cebpa protein (Lin et al. 1993, Calkhoven et al. 2000). Depending on which initiation codon is used, the Cebpa mRNA can be translated to yield a 35.9 kDa protein (p42) or a 25.5 kDa protein (p30) (Lin et al. 1993, Calkhoven et al. 2000). Cebpa protein is then imported into the nucleus. The p30 isoform is not antimitotic (Lin et al. 1993).
Literature References
PubMed ID Title Journal Year
8415748 A 30-kDa alternative translation product of the CCAAT/enhancer binding protein alpha message: transcriptional activator lacking antimitotic activity

Lane, MD, Lin, FT, MacDougald, OA, Diehl, AM

Proc. Natl. Acad. Sci. U.S.A. 1993
10921906 Translational control of C/EBPalpha and C/EBPbeta isoform expression

Leutz, A, Calkhoven, CF, Müller, C

Genes Dev. 2000
Participants
Input
Output
Orthologous Events
CEBPA mRNA is translated to yield CEBPA protein (Homo sapiens)
Authored
May, B  (2018-10-27)
Reviewed
Skokowa, J  (2019-03-10)
Created
May, B  (2018-10-27)
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