Reactome | phospho-Ptk2 [cytosol]

phospho-Ptk2 [cytosol]

Stable Identifier

R-MMU-9632393

Type

Protein [EntityWithAccessionedSequence]

Species

Mus musculus

Compartment

cytosol

Synonyms

pY-PTK2, P34152

Locations in the PathwayBrowser for interactor UniProt:P49023

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External Reference Information

External Reference

UniProt:P34152 Ptk2

Gene Names

Ptk2, Fadk, Fak, Fak1, Kiaa4203

Chain

initiator methionine:1, chain:2-1052

Reference Genes

BioGPS Gene:14083 Ptk2

ENSEMBL:ENSMUSG00000022607 Ptk2

KEGG Gene (Mus musculus):14083 Ptk2

Monarch:14083 Ptk2

NCBI Gene:14083 Ptk2

UCSC:P34152 Ptk2

Reference Transcript

Other Identifiers

10429341

14083

1423059_at

1430827_a_at

167825_r_at

17317858

4386227

4401103

4407572

4441659

4524128

4557284

4619807

4622929

4647920

4703443

4781786

4797825

4803357

4815069

4816125

4819792

4864803

4890851

4907985

4931592

4946451

4970816

5100085

5117839

5123711

5177069

5191803

5205664

5208425

5255998

5267333

5318829

5343889

5382571

5387586

5398524

5459628

5464361

5534854

5556700

5575936

5597162

5614128

97363_at

A_51_P216219

A_52_P359381

A_55_P2349265

GE34373

GO:0003674

GO:0004672

GO:0004713

GO:0005524

GO:0005575

GO:0005622

GO:0005856

GO:0005925

GO:0006464

GO:0006468

GO:0007165

GO:0007172

GO:0008150

GO:0016301

GO:0022607

GO:0043167

GO:0043226

GO:0065003

ILMN_1240840

ILMN_2615901

M95408_s_at

mMC010925

Participates

as an input of

PTK2 is recruited to methylated ESR1 (Mus musculus)

as a component of

Me260-ESR1:STRN:ESTG: MyrG-pY419 SRC:PI3Kalpha:pY-PTK2 [plasma membrane] (Mus musculus)

Other forms of this molecule

p-Y428-FAK1 [cytosol]

phospho-Ptk2 [cytosol]

Ptk2 [cytosol]

phospho-Ptk2 [cytosol]

Fak1 [cytosol]

Inferred From

pY-PTK2 [cytosol] (Homo sapiens)

Modified Residues

Name

O4'-phospho-L-tyrosine at unknown position

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Cross References

RefSeq

XP_006520496.1, NP_001123881.1, NP_032008.2

Ensembl

ENSMUSP00000155470, ENSMUST00000228180, ENSMUST00000226988, ENSMUSP00000154242, ENSMUST00000110036, ENSMUSG00000022607, ENSMUSP00000105663

PRO

P34152

MGI

95481

PDB

5F28, 1KKY, 1K40, 1KL0, 6BZ3

Interactors (8)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q8VI36	4	Pxn [plasma membrane] (R-MMU-180493) phospho-Pxn [plasma membrane] (R-MMU-9031680) Pxn [cytosol] (R-MMU-210014) phospho-Pxn [cytosol] (R-MMU-5218693)	0.784	6
UniProt:Q61140 Bcar1	6	p-12Y-P130Cas [cytosol] (R-MMU-5218727) phospho-Bcar1 [cytosol] (R-MMU-372645) Bcar1 [cytosol] (R-MMU-201625) phospho-Bcar1 [cytosol] (R-MMU-8848723) phospho-Bcar1 [cytosol] (R-MMU-5218739) p130Cas [cytosol] (R-MMU-5218743)	0.646	3
UniProt:P62993 GRB2	1	GRB2 [cytosol] (R-HSA-8983328)	0.597	3
UniProt:P12931 SRC	6	p-Y416-SRC [cytosol] (R-HSA-8964276) SRC [cytosol] (R-HSA-9628701) p-Y419-SRC [nucleoplasm] (R-HSA-8937690) MyrG-SRC [plasma membrane] (R-HSA-8876922) MyrG,p-Y530-SRC [plasma membrane] (R-HSA-377598) MyrG-p-Y419-SRC [plasma membrane] (R-HSA-1810408)	0.564	2
UniProt:Q60631 Grb2	3	Grb2 [plasma membrane] (R-MMU-202993) Grb2 [cytosol] (R-MMU-74686) Grb2 [cytosol] (R-MMU-443287)	0.508	2
UniProt:Q99JY9	1	Actr3 [cytosol] (R-MMU-200811)	0.463	2
UniProt:P54763 Ephb2	9	p-Ephb2 [plasma membrane] (R-MMU-3928433) phospho-Ephb2 [plasma membrane] (R-MMU-3928375) Ephb2 [plasma membrane] (R-MMU-443809) Ephb2 [extracellular region] (R-MMU-3928436) Ephb2 [plasma membrane] (R-MMU-3928386) Ephb2 [cytosol] (R-MMU-3928432) Ephb2 [plasma membrane] (R-MMU-3928394) Ephb2 [plasma membrane] (R-MMU-3928443) p-Y604,Y610-Ephb2 [plasma membrane] (R-MMU-4093312)	0.463	3
UniProt:P49023 PXN	4	PXN [plasma membrane] (R-HSA-180493) p-Y-PXN [plasma membrane] (R-HSA-9031680) PXN [cytosol] (R-HSA-210014) p-Y31,Y118-PXN [cytosol] (R-HSA-5218693)	0.463	2

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