Reactome | Rpl23a [cytosol]

Rpl23a [cytosol]

Stable Identifier

R-MMU-9633537

Type

Protein [EntityWithAccessionedSequence]

Species

Mus musculus

Compartment

cytosol

Synonyms

60S ribosomal protein L23a, RL23A_MOUSE

Locations in the PathwayBrowser

Expand all

Metabolism of RNA (Mus musculus)

- Nonsense-Mediated Decay (NMD) (Mus musculus)
  - Nonsense Mediated Decay (NMD) enhanced by the Exon Junction Complex (EJC) (Mus musculus)
    - SMG1 phosphorylates UPF1 (enhanced by Exon Junction Complex) (Mus musculus)
      - SMG1:Phosphorylated UPF1:EJC:Translated mRNP [cytosol] (Mus musculus)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Mus musculus)
        
        80S ribosome [cytosol] (Mus musculus)
        
        60S ribosomal complex [cytosol] (Mus musculus)
        
        Rpl23a [cytosol] (Mus musculus)
      - SMG1:UPF1:EJC:Translated mRNP [cytosol] (Mus musculus)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Mus musculus)
        
        80S ribosome [cytosol] (Mus musculus)
        
        60S ribosomal complex [cytosol] (Mus musculus)
        
        Rpl23a [cytosol] (Mus musculus)
    - SMG6 hydrolyzes mRNA with premature termination codon (Mus musculus)
      - Phosphorylated UPF1:SMG5:SMG7:SMG6:PP2A:Translated mRNP [cytosol] (Mus musculus)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Mus musculus)
        
        80S ribosome [cytosol] (Mus musculus)
        
        60S ribosomal complex [cytosol] (Mus musculus)
        
        Rpl23a [cytosol] (Mus musculus)
    - UPF1 binds an mRNP with a termination codon preceding an Exon Junction Complex (Mus musculus)
      - SMG1:UPF1:EJC:Translated mRNP [cytosol] (Mus musculus)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Mus musculus)
        
        80S ribosome [cytosol] (Mus musculus)
        
        60S ribosomal complex [cytosol] (Mus musculus)
        
        Rpl23a [cytosol] (Mus musculus)
      - Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Mus musculus)
        
        80S ribosome [cytosol] (Mus musculus)
        
        60S ribosomal complex [cytosol] (Mus musculus)
        
        Rpl23a [cytosol] (Mus musculus)
    - p-4S-UPF1 recruits SMG5, SMG7, SMG6, PNRC2, DCP1A, and PP2A (Mus musculus)
      - Phosphorylated UPF1:SMG5:SMG7:SMG6:PP2A:Translated mRNP [cytosol] (Mus musculus)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Mus musculus)
        
        80S ribosome [cytosol] (Mus musculus)
        
        60S ribosomal complex [cytosol] (Mus musculus)
        
        Rpl23a [cytosol] (Mus musculus)
      - SMG1:Phosphorylated UPF1:EJC:Translated mRNP [cytosol] (Mus musculus)
        
        Translated mRNA Complex with Premature Termination Codon Preceding Exon Junction [cytosol] (Mus musculus)
        
        80S ribosome [cytosol] (Mus musculus)
        
        60S ribosomal complex [cytosol] (Mus musculus)
        
        Rpl23a [cytosol] (Mus musculus)
  - Nonsense Mediated Decay (NMD) independent of the Exon Junction Complex (EJC) (Mus musculus)
    - Formation of UPF1:eRF3 complex on mRNA with a premature termination codon and no Exon Junction Complex (Mus musculus)
      - Translated mRNA Complex with Premature Termination Codon Not Preceding Exon Junction [cytosol] (Mus musculus)
        
        80S ribosome [cytosol] (Mus musculus)
        
        60S ribosomal complex [cytosol] (Mus musculus)
        
        Rpl23a [cytosol] (Mus musculus)
      - UPF1:eRF3 Complex on Translated mRNA [cytosol] (Mus musculus)
        
        Translated mRNA Complex with Premature Termination Codon Not Preceding Exon Junction [cytosol] (Mus musculus)
        
        80S ribosome [cytosol] (Mus musculus)
        
        60S ribosomal complex [cytosol] (Mus musculus)
        
        Rpl23a [cytosol] (Mus musculus)
- rRNA processing (Mus musculus)
  - rRNA processing in the nucleus and cytosol (Mus musculus)
    - Major pathway of rRNA processing in the nucleolus and cytosol (Mus musculus)
      - 12S pre-rRNA is nucleolytically processed to yield 5.8S rRNA (Mus musculus)
        
        60S ribosomal complex [cytosol] (Mus musculus)
        
        Rpl23a [cytosol] (Mus musculus)

External Reference Information

External Reference

UniProt:P62751 Rpl23a

Gene Names

Rpl23a

Chain

initiator methionine:, chain:2-156

Reference Genes

BioGPS Gene:268449 Rpl23a

ENSEMBL:ENSMUSG00000058546.9 Rpl23a

KEGG Gene (Mus musculus):268449 Rpl23a

Monarch:268449 Rpl23a

NCBI Gene:268449 Rpl23a

UCSC:P62751 Rpl23a

Reference Transcript

RefSeq:NM_207523.2 Rpl23a

Other Identifiers

10346105

10350990

10361816

10371265

10371267

10371269

10371275

10388776

10414078

10421707

10579657

10598103

10598831

108168140

1426659_a_at

1426660_x_at

1437975_a_at

1437976_x_at

17243456

17243458

17266362

17298791

268449

4307620

4691410

4719641

4723557

4739660

4769921

4835971

4955954

5001711

5013219

5118794

5156762

5257691

5370499

5419048

5557192

94823_at

A_55_P2109874

GO:0000027

GO:0002181

GO:0003723

GO:0003735

GO:0005198

GO:0005515

GO:0005634

GO:0005737

GO:0005829

GO:0005840

GO:0006412

GO:0008150

GO:0019843

GO:0022625

GO:0022626

GO:0042254

GO:0043226

GO:0044391

GO:0045202

GO:0065003

GO:0070180

GO:0098793

GO:0098794

GO:0140236

GO:0140242

GO:1904841

GO:1990904

ILMN_1236631

aa538407_s_at

mMC025201

Participates

as a component of

Inferred From

RPL23A [cytosol] (Homo sapiens)

Cross References

RefSeq

NP_997406.1

Ensembl

ENSMUST00000102483, ENSMUSP00000099541, ENSMUSG00000058546

PRO

P62751

MGI

3040672

PDB

6SWA, 7LS1, 7LS2, 7CPV, 7CPU

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