Gfi1 gene expression is enhanced by Cebpa

Stable Identifier
R-MMU-9634432
Type
Reaction [omitted]
Species
Mus musculus
Compartment
General
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Gfi1 gene expression is enhanced by Cebpa

Cebpa bound to the promoter of the Gfi1 gene activates transcription of Gfi1 approximately 3-fold (Lidonnici et al 2010, Ma et al. 2014). Activation of the transcription repressor Gfi1 by Cebpa is required for the inhibition of cellular proliferation caused by Cebpa (Lidonnici et al. 2010).

Literature References
PubMed ID Title Journal Year
20924107 Expression of the transcriptional repressor Gfi-1 is regulated by C/EBP{alpha} and is involved in its proliferation and colony formation-inhibitory effects in p210BCR/ABL-expressing cells

Lidonnici, MR, Audia, A, Soliera, AR, Prisco, M, Ferrari-Amorotti, G, Waldron, T, Donato, N, Zhang, Y, Martinez, RV, Holyoake, TL, Calabretta, B

Cancer Res. 2010
24752325 Granulopoiesis requires increased C/EBPα compared to monopoiesis, correlated with elevated Cebpa in immature G-CSF receptor versus M-CSF receptor expressing cells

Ma, O, Hong, S, Guo, H, Ghiaur, G, Friedman, AD

PLoS ONE 2014
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