Gfi1 gene expression is enhanced by Cebpa

Stable Identifier
R-MMU-9634432
Type
Reaction [omitted]
Species
Mus musculus
Compartment
nucleoplasm, cytosol
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Gfi1 gene expression is enhanced by Cebpa
Cebpa bound to the promoter of the Gfi1 gene activates transcription of Gfi1 approximately 3-fold (Lidonnici et al 2010, Ma et al. 2014). Activation of the transcription repressor Gfi1 by Cebpa is required for the inhibition of cellular proliferation caused by Cebpa (Lidonnici et al. 2010).
Literature References
PubMed ID Title Journal Year
24752325 Granulopoiesis requires increased C/EBPα compared to monopoiesis, correlated with elevated Cebpa in immature G-CSF receptor versus M-CSF receptor expressing cells

Guo, H, Ghiaur, G, Hong, S, Friedman, AD, Ma, O

PLoS ONE 2014
20924107 Expression of the transcriptional repressor Gfi-1 is regulated by C/EBP{alpha} and is involved in its proliferation and colony formation-inhibitory effects in p210BCR/ABL-expressing cells

Calabretta, B, Soliera, AR, Ferrari-Amorotti, G, Martinez, RV, Zhang, Y, Prisco, M, Lidonnici, MR, Audia, A, Holyoake, TL, Waldron, T, Donato, N

Cancer Res. 2010
Participants
Input
Output
This event is regulated
Positively by
Regulator
Gfi1 gene:Cebpa dimer [nucleoplasm] (Mus musculus)
Orthologous Events
GFI1 gene expression is enhanced by CEBPA (Homo sapiens)
Authored
May, B  (2018-08-15)
Reviewed
Skokowa, J  (2019-03-10)
Created
May, B  (2019-01-11)
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