Cebpe gene expression is enhanced by Cebpa

Stable Identifier
R-MMU-9634434
Type
Reaction [omitted]
Species
Mus musculus
Compartment
nucleoplasm, cytosol
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Cebpe gene expression is enhanced by Cebpa
Cebpa bound to the promoter of the Cebpe gene activates transcription (Wang and Friedman 2002, Zhang et al. 2002, Friedman et al.2003, Ma et al. 2014). Transcription of Cebpe can also be activated by IL-3 and Csf2 (GM-CSF) independently of Cebpa (Ma et al. 2014).
Literature References
PubMed ID Title Journal Year
11929766 CCAAT/enhancer-binding proteins are required for granulopoiesis independent of their induction of the granulocyte colony-stimulating factor receptor

Friedman, AD, Wang, QF

Blood 2002
12036869 Induction of granulocytic differentiation by 2 pathways

Radomska, HS, Friedman, AD, Iwasaki-Arai, J, Zhang, P, Tenen, DG, Nelson, E, Akashi, K

Blood 2002
24752325 Granulopoiesis requires increased C/EBPα compared to monopoiesis, correlated with elevated Cebpa in immature G-CSF receptor versus M-CSF receptor expressing cells

Guo, H, Ghiaur, G, Hong, S, Friedman, AD, Ma, O

PLoS ONE 2014
14636649 Regulation of granulocyte and monocyte differentiation by CCAAT/enhancer binding protein alpha

Friedman, AD, Kummalue, T, Cleaves, R, Liu, H, Keefer, JR, Wang, QF

Blood Cells Mol. Dis. 2003
Participants
Input
Output
This event is regulated
Positively by
Regulator
Cebpe gene:Cepba dimer [nucleoplasm] (Mus musculus)
Orthologous Events
CEBPE gene expression is enhanced by CEBPA, SPI1 (PU.1), and retinoic acid (Homo sapiens)
Authored
May, B  (2018-08-14)
Reviewed
Skokowa, J  (2019-03-10)
Created
May, B  (2019-01-11)
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