PolyUb-Misfolded Proteins:Hdac6 dissociate from complex

Stable Identifier
R-MMU-9646359
Type
Reaction [dissociation]
Species
Mus musculus
Compartment
General
SVG |   | PPTX  | SBGN
PolyUb-Misfolded Proteins:Hdac6 dissociate from complex

Misfolded proteins are poly-ubiquitinated and bind a complex comprising of Transitional endoplasmic reticulum ATPase (Vcp), Histone deacetylase 6 (Hdac6), Heat shock protein HSP 90 (Hsp90) and Heat shock factor protein 1 (Hsf1). This binding causes the dissociation of the complex resulting in Hdac6 bound-ubiquitinated proteins and a complex of Hsp90:Hsf1 (Boyault C et al. 2007).

Literature References
PubMed ID Title Journal Year
17785525 HDAC6 controls major cell response pathways to cytotoxic accumulation of protein aggregates

Boyault, C, Zhang, Y, Fritah, S, Caron, C, Gilquin, B, Kwon, SH, Garrido, C, Yao, TP, Vourc'h, C, Matthias, P, Khochbin, S

Genes Dev. 2007
Participants
Orthologous Events
Authored
Reviewed
Created
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