Translation of Atf5

Stable Identifier
R-MMU-9653710
Type
Reaction [BlackBoxEvent]
Species
Mus musculus
Compartment
General
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Translation of Atf5

The Atf5 mRNA is translated to yield Atf5 protein (Zhou et al. 2008, Zhang et al. 2019) which is then imported into the nucleus. The Atf5 mRNA contains 2 upstream ORFs (uORFs) which inhibit translation of the downstream Atf5 coding region (Zhou et al. 2008). During certain stresses, Eif2s1 (eIF2-alpha) is phosphorylated, decreasing translation initiation at the uORFs and increasing translation of Atf5 (Zhou et al. 2008, Zhang et al. 2019).

Literature References
PubMed ID Title Journal Year
18195013 Phosphorylation of eIF2 directs ATF5 translational control in response to diverse stress conditions

Zhou, D, Palam, LR, Jiang, L, Narasimhan, J, Staschke, KA, Wek, RC

J. Biol. Chem. 2008
31033440 HRI coordinates translation necessary for protein homeostasis and mitochondrial function in erythropoiesis

Zhang, S, Macias-Garcia, A, Ulirsch, JC, Velazquez, J, Butty, VL, Levine, SS, Sankaran, VG, Chen, JJ

Elife 2019
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