Transcription of Ppp1r15a

Stable Identifier
R-MMU-9654771
Type
Reaction [omitted]
Species
Mus musculus
Compartment
nucleoplasm
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Transcription of Ppp1r15a
The Ppp1r15a gene is transcribed to yield mRNA (Ma and Hendershot 2003, Zhang et al. 2019). Transcription of Ppp1r15a is activated by Atf4, which binds the Ppp1r15a promoter in response to certain stresses such as endoplasmic reticulum stress (Ma and Hendershot 2003), traumatic brain injury (Farook et al. 2013), and heme deficiency (Zhang et al. 2019).
Literature References
PubMed ID Title Journal Year
23907468 GADD34 induces cell death through inactivation of Akt following traumatic brain injury

Sen, N, Shields, J, Dhandapani, KM, Farook, JM, Sen, T, Tawfik, A, Smith, SB, Brann, D, Markand, S

Cell Death Dis 2013
31033440 HRI coordinates translation necessary for protein homeostasis and mitochondrial function in erythropoiesis

Macias-Garcia, A, Zhang, S, Butty, VL, Levine, SS, Sankaran, VG, Velazquez, J, Ulirsch, JC, Chen, JJ

Elife 2019
12840028 Delineation of a negative feedback regulatory loop that controls protein translation during endoplasmic reticulum stress

Ma, Y, Hendershot, LM

J. Biol. Chem. 2003
Participants
Input
Output
This event is regulated
Positively by
Regulator
Atf4:Ppp1r15a gene [nucleoplasm] (Mus musculus)
Orthologous Events
Transcription of PPP1R15A (Homo sapiens)
Authored
May, B  (2019-07-18)
Reviewed
Chen, JJ  (2019-10-22)
Created
May, B  (2019-07-19)
Cite Us!