Slc25a44 transports Leu, Ile and Val from cytosol to mitochondrial matrix

Stable Identifier
R-MMU-9673827
Type
Reaction [transition]
Species
Mus musculus
Compartment
General
SVG |   | PPTX  | SBGN
Slc25a44 transports Leu, Ile and Val from cytosol to mitochondrial matrix

Mitochondrial uptake of the three branched-chain amino acids leucine (Leu), isoleucine (Ile), and valine (Val) is mediated by solute carrier family 25 member 44 (Slc25a44), localized in the inner mitochondrial membrane, as demonstrated by studies of studies of knockout mice and of liposomes rconstituted with recombinant protein (Yoneshiro et al. 2019).

Literature References
PubMed ID Title Journal Year
31435015 BCAA catabolism in brown fat controls energy homeostasis through SLC25A44

Yoneshiro, T, Wang, Q, Tajima, K, Matsushita, M, Maki, H, Igarashi, K, Dai, Z, White, PJ, McGarrah, RW, Ilkayeva, OR, Deleye, Y, Oguri, Y, Kuroda, M, Ikeda, K, Li, H, Ueno, A, Ohishi, M, Ishikawa, T, Kim, K, Chen, Y, Sponton, CH, Pradhan, RN, Majd, H, Greiner, VJ, Yoneshiro, M, Brown, Z, Chondronikola, M, Takahashi, H, Goto, T, Kawada, T, Sidossis, L, Szoka, FC, McManus, MT, Saito, M, Soga, T, Kajimura, S

Nature 2019
Participants
Event Information
Catalyst Activity
Catalyst Activity
Title
branched-chain amino acid transmembrane transporter activity of Slc25a44 [mitochondrial inner membrane]
Physical Entity
Activity
Orthologous Events
Authored
Reviewed
Created
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