p-Y-Jak1,2 phosphorylates Stat1,3,5 in Csf3 dimer:2xp-4Y-Csf3r:Lyn:p-Y-Jak1:p-Jak2:p-Tyk2:Stat1,3,5

Stable Identifier
R-MMU-9674908
Type
Reaction [transition]
Species
Mus musculus
Compartment
plasma membrane
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
p-Y-Jak1,2 phosphorylates Stat1,3,5 in Csf3 dimer:2xp-4Y-Csf3r:Lyn:p-Y-Jak1:p-Jak2:p-Tyk2:Stat1,3,5
Phosphorylated Jak1 (p-Y-Jak1) phosphorylates the Stat proteins Stat1 (de Koning et al. 1996, Nicholson et al. 1996, Shimoda et al. 1997), Stat3 (Nicholson et al. 1995, de Koning et al. 1996, Nicholson et al. 1996, Shimoda et al. 1997, Chakraborty et al. 1999, de Koning et al. 2000), and Stat5 (de Koning et al. 1996, Nicholson et al. 1996, Shimoda et al. 1997, Dong et al. 1998, Ward et al. 1999, Gits et al. 2006) at the cytosolic domain of Csf3r (G-CSFR). Phosphorylated Jak2 acts redundantly with p-Y-Jak1 to phosphorylate Stat proteins (Gits et al. 2006).
Literature References
PubMed ID Title Journal Year
7579336 Distinct regions of the granulocyte colony-stimulating factor receptor are required for tyrosine phosphorylation of the signaling molecules JAK2, Stat3, and p42, p44MAPK

Novak, U, Layton, JE, Nicholson, SE, Ziegler, SF

Blood 1995
8900180 Tyrosine residues in the granulocyte colony-stimulating factor (G-CSF) receptor mediate G-CSF-induced differentiation of murine myeloid leukemic (M1) cells

Novak, U, Layton, JE, Nicholson, SE, Hilton, DJ, Starr, R

J. Biol. Chem. 1996
9226159 Jak1 plays an essential role for receptor phosphorylation and Stat activation in response to granulocyte colony-stimulating factor

Nagata, S, Ihle, JN, Murakami, H, Stark, GR, Rogers, NC, Feng, J, Shimoda, K, Kerr, IM, Watling, D

Blood 1997
10918585 STAT3-mediated differentiation and survival and of myeloid cells in response to granulocyte colony-stimulating factor: role for the cyclin-dependent kinase inhibitor p27(Kip1)

Schelen, AM, Ward, AC, Touw, IP, Löwenberg, B, van Leeuwen, D, de Koning, JP, Soede-Bobok, AA, Antonissen, C

Oncogene 2000
9862674 Stimulation of Stat5 by granulocyte colony-stimulating factor (G-CSF) is modulated by two distinct cytoplasmic regions of the G-CSF receptor

Touw, IP, Dong, F, de Koning, JP, Liu, X, Grimley, PM, Hennighausen, L, Larner, A

J Immunol 1998
10329697 Multiple signals mediate proliferation, differentiation, and survival from the granulocyte colony-stimulating factor receptor in myeloid 32D cells

Smith, L, Ward, AC, Touw, IP, van Aesch, Y, de Koning, JP

J. Biol. Chem. 1999
8608222 The membrane-distal cytoplasmic region of human granulocyte colony-stimulating factor receptor is required for STAT3 but not STAT1 homodimer formation

van der Plas, DC, Schelen, AM, Barge, RM, Smith, L, Touw, IP, Löwenberg, B, Dong, F, de Koning, JP, Hoefsloot, LH

Blood 1996
17066093 Multiple pathways contribute to the hyperproliferative responses from truncated granulocyte colony-stimulating factor receptors

Ward, AC, Touw, IP, Carroll, HP, van Leeuwen, D, Gits, J

Leukemia 2006
9864141 Identification of a novel Stat3 recruitment and activation motif within the granulocyte colony-stimulating factor receptor

Tweardy, DJ, Dyer, KF, Chakraborty, A, Cascio, M, Mietzner, TA

Blood 1999
Participants
Input
Output
Catalyst Activity

protein tyrosine kinase activity of Csf3 dimer:2xp-4Y-Csf3r:Lyn:p-Y-Jak1:p-Jak2:p-Syk:p-Hck:p-Tyk2:Stat1,3,5 [plasma membrane]

Physical Entity
Csf3 dimer:2xp-4Y-Csf3r:Lyn:p-Y-Jak1:p-Jak2:p-Syk:p-Hck:p-Tyk2:Stat1,3,5 [plasma membrane] (Mus musculus)
Activity
protein tyrosine kinase activity (GO:0004713)
Orthologous Events
p-Y-JAK1,2 phosphorylates STAT1,3,5 in CSF3 dimer:2xp-4Y-CSF3R:LYN:p-Y-JAK1:p-Y-JAK2:p-TYK2 (Homo sapiens)
Authored
May, B  (2020-01-27)
Reviewed
Touw, IP  (2020-12-12)
Created
May, B  (2020-01-29)
Cite Us!