p-Y-Stat1,3,5 dimer translocates from the cytosol to the nucleus

Stable Identifier
R-MMU-9676907
Type
Reaction [omitted]
Species
Mus musculus
Compartment
cytosol, nucleoplasm
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
p-Y-Stat1,3,5 dimer translocates from the cytosol to the nucleus
Homodimers of phosphorylated Stat1, Stat3, and Stat5 and heterodimers of phosphorylated Stat1 and Stat3 translocate from the cytosol to the nucleus (Nicholson et al. 1995, de Koning et al. 1996, Ward et al. 1999, Gits et al. 2006).
Literature References
PubMed ID Title Journal Year
7579336 Distinct regions of the granulocyte colony-stimulating factor receptor are required for tyrosine phosphorylation of the signaling molecules JAK2, Stat3, and p42, p44MAPK

Novak, U, Layton, JE, Nicholson, SE, Ziegler, SF

Blood 1995
8608222 The membrane-distal cytoplasmic region of human granulocyte colony-stimulating factor receptor is required for STAT3 but not STAT1 homodimer formation

van der Plas, DC, Schelen, AM, Barge, RM, Smith, L, Touw, IP, Löwenberg, B, Dong, F, de Koning, JP, Hoefsloot, LH

Blood 1996
17066093 Multiple pathways contribute to the hyperproliferative responses from truncated granulocyte colony-stimulating factor receptors

Ward, AC, Touw, IP, Carroll, HP, van Leeuwen, D, Gits, J

Leukemia 2006
Participants
Input
Output
Orthologous Events
p-Y-STAT1,3,5 dimer translocates from the cytosol to the nucleoplasm (Homo sapiens)
Authored
May, B  (2020-02-23)
Reviewed
Touw, IP  (2020-12-12)
Created
May, B  (2020-02-23)
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