Expression of Sox9 in testis differentiation

Stable Identifier
R-MMU-9690416
Type
Reaction [omitted]
Species
Mus musculus
Compartment
nucleoplasm
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Expression of Sox9 in testis differentiation
Sry and Nr5a1 bound at the TES enhancer upstream of the Sox9 gene (Sekido and Lovell-Badge 2008) and other enhancers (Gonen et al. 2017) activate transcription of Sox9 (Kidokoro et al. 2005, Sekido and Lovell-Badge 2008, Matoba et al. 2008, Gonen et al. 2017). Later in development, expression of Sry ceases and Sox9 activates expression of its own gene (Sekido and Lovell-Badge 2008). Dmrt1, itself directly activated by Sox9, also directly activates Sox9 (Matson et al. 2011, Lindeman et al. 2015). Fgf9 acting through Fgfr2 and Prostaglandin D2 activate Sox9 through less well characterized mechanisms (Kim et al. 2006).
Literature References
PubMed ID Title Journal Year
18823970 Establishment of testis-specific SOX9 activation requires high-glucose metabolism in mouse sex differentiation

Harikae, K, Hiramatsu, R, Kawakami, H, Kanai, Y, Matoba, S, Tsunekawa, N, Kanai-Azuma, M, Kurohmaru, M

Dev. Biol. 2008
18454134 Sex determination involves synergistic action of SRY and SF1 on a specific Sox9 enhancer

Sekido, R, Lovell-Badge, R

Nature 2008
15680367 Influence on spatiotemporal patterns of a male-specific Sox9 activation by ectopic Sry expression during early phases of testis differentiation in mice

Hiramatsu, R, Kawakami, H, Fujisawa, M, Kidokoro, T, Yonekawa, H, Kanai, Y, Hayashi, Y, Matoba, S, Kanai-Azuma, M, Kurohmaru, M, Taya, C

Dev. Biol. 2005
28045957 Normal Levels of Sox9 Expression in the Developing Mouse Testis Depend on the TES/TESCO Enhancer, but This Does Not Act Alone

Koopman, P, O'Neill, HC, Gonen, N, Quinn, A, Lovell-Badge, R

PLoS Genet. 2017
Participants
Input
Output
This event is regulated
Positively by
Regulator
Dmrt1:Sox9 gene [nucleoplasm] (Mus musculus)
Regulator
Sox9:Nr5a1:Sox9 gene [nucleoplasm] (Mus musculus)
Regulator
Sry:Nr5a1:Sox9 gene [nucleoplasm] (Mus musculus)
Regulator
Fgf9 [extracellular region] (Mus musculus)
Orthologous Events
Expression of SOX9 in testis differentiation (Homo sapiens)
Authored
May, B  (2020-05-24)
Reviewed
Imaimatsu, K  (2020-10-29)
Kanai, Y  (2020-10-29)
Created
May, B  (2020-05-31)
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