Expression of Ptgds in testis differentiation

Stable Identifier
R-MMU-9692138
Type
Reaction [omitted]
Species
Mus musculus
Compartment
nucleoplasm
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Expression of Ptgds in testis differentiation
In the developing testis, the Ptgds gene is transcribed to yield mRNA and the mRNA is translated to yield Ptgds protein (Wilhelm et al. 2007, Moniot et al. 2009, Li et al. 2014). Transcription of Ptgds is directly activated by Sox9 during testis differentiation (Wilhelm et al. 2007, Moniot et al. 2009, Li et al. 2014).
Literature References
PubMed ID Title Journal Year
25088423 The sex-determining factors SRY and SOX9 regulate similar target genes and promote testis cord formation during testicular differentiation

Zheng, M, Lau, YF, Li, Y

Cell Rep 2014
19429785 The PGD2 pathway, independently of FGF9, amplifies SOX9 activity in Sertoli cells during male sexual differentiation

Moniot, B, Declosmenil, F, Scherer, G, Georg, I, Eguchi, N, Boizet-Bonhoure, B, Urade, Y, Capel, B, Cohen-Solal, A, Klattig, J, Englert, C, Malki, S, Barrionuevo, FJ, Poulat, F, Aritake, K, Kim, Y, Marzi, L

Development 2009
17277314 SOX9 regulates prostaglandin D synthase gene transcription in vivo to ensure testis development

Hiramatsu, R, Wilhelm, D, Koopman, P, Combes, AN, Mizusaki, H, Widjaja, L, Kanai, Y

J. Biol. Chem. 2007
Participants
Input
Output
This event is regulated
Positively by
Regulator
Sox9:Ptgds gene [nucleoplasm] (Mus musculus)
Orthologous Events
Expression of PTGDS in testis differentiation (Homo sapiens)
Authored
May, B  (2020-06-15)
Reviewed
Imaimatsu, K  (2020-10-29)
Kanai, Y  (2020-10-29)
Created
May, B  (2020-06-20)
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