Reactome | Expression of Amh in testis differentiation

Expression of Amh in testis differentiation

Stable Identifier

R-MMU-9692156

Type

Reaction [omitted]

Species

Mus musculus

Compartment

nucleoplasm, extracellular region

ReviewStatus

5/5

General

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Expression of Amh in testis differentiation

In differentiating Sertoli cells of the testis, the Amh gene is transcribed to yield mRNA and the mRNA is translated to yield Amh protein (Arango et al. 1999, Li et al. 2014). Sox9, Nr5a1 (SF1), and Gata4 bind the promoter of the Amh gene and activate transcription (Arango et al. 1999, Li et al. 2014).

Literature References

PubMed ID	Title	Journal	Year
25088423	The sex-determining factors SRY and SOX9 regulate similar target genes and promote testis cord formation during testicular differentiation Zheng, M, Lau, YF, Li, Y	Cell Rep	2014
10571183	Targeted mutagenesis of the endogenous mouse Mis gene promoter: in vivo definition of genetic pathways of vertebrate sexual development Lovell-Badge, R, Arango, NA, Behringer, RR	Cell	1999

Participants

Input

Amh gene [nucleoplasm] (Mus musculus)

Output

Amh [extracellular region] (Mus musculus)

This event is regulated

Positively by

Regulator

Sox9:Nr5a1:Gata4:Amh gene [nucleoplasm] (Mus musculus)

Orthologous Events

Expression of AMH in testis differentiation (Homo sapiens)

Authored

May, B (2020-06-15)

Reviewed

Imaimatsu, K (2020-10-29)

Kanai, Y (2020-10-29)

Created

May, B (2020-06-20)

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