Wt1, Nr5a1 (Sf1), Gata4, Zfpm2 (Fog2) bind the Sry gene

Stable Identifier
R-MMU-9692234
Type
Reaction [binding]
Species
Mus musculus
Compartment
nucleoplasm
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Wt1, Nr5a1 (Sf1), Gata4, Zfpm2 (Fog2) bind the Sry gene

The transcription factors Wt1 (Miyamoto et al. 2008), Nr5a1 (SF1), Gata4:Zfpm2 (Gata4:Fog2, Miyamoto et al. 2008, Gierl et al. 2012) bind the promoter of the Sry gene and activate transcription of Sry. Sry is a mammal-specific gene located on the Y chromosome that is responsible for male sex determination.

Literature References
PubMed ID Title Journal Year
23102581 GADD45G functions in male sex determination by promoting p38 signaling and Sry expression

Gierl, MS, Gruhn, WH, von Seggern, A, Maltry, N, Niehrs, C

Dev. Cell 2012
18445271 A GATA4/WT1 cooperation regulates transcription of genes required for mammalian sex determination and differentiation

Miyamoto, Y, Taniguchi, H, Hamel, F, Silversides, DW, Viger, RS

BMC Mol. Biol. 2008
Participants
Input
Output
Orthologous Events
WT1, NR5A1 (SF1), GATA4, ZFPM2 bind the SRY gene (Homo sapiens)
Authored
May, B  (2020-06-22)
Reviewed
Kanai, Y  (2020-10-29)
Imaimatsu, K  (2020-10-29)
Created
May, B  (2020-06-22)
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