Wt1, Nr5a1 (Sf1), Gata4, Zfpm2 (Fog2) bind the Sry gene

Stable Identifier
R-MMU-9692234
Type
Reaction [binding]
Species
Mus musculus
Compartment
nucleoplasm
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Wt1, Nr5a1 (Sf1), Gata4, Zfpm2 (Fog2) bind the Sry gene
The transcription factors Wt1 (Miyamoto et al. 2008), Nr5a1 (SF1), Gata4:Zfpm2 (Gata4:Fog2, Miyamoto et al. 2008, Gierl et al. 2012) bind the promoter of the Sry gene and activate transcription of Sry. Sry is a mammal-specific gene located on the Y chromosome that is responsible for male sex determination.
Literature References
PubMed ID Title Journal Year
18445271 A GATA4/WT1 cooperation regulates transcription of genes required for mammalian sex determination and differentiation

Taniguchi, H, Viger, RS, Miyamoto, Y, Silversides, DW, Hamel, F

BMC Mol. Biol. 2008
23102581 GADD45G functions in male sex determination by promoting p38 signaling and Sry expression

von Seggern, A, Niehrs, C, Gruhn, WH, Gierl, MS, Maltry, N

Dev. Cell 2012
Participants
Input
Output
Orthologous Events
WT1, NR5A1 (SF1), GATA4, ZFPM2 bind the SRY gene (Homo sapiens)
Authored
May, B  (2020-06-22)
Reviewed
Imaimatsu, K  (2020-10-29)
Kanai, Y  (2020-10-29)
Created
May, B  (2020-06-22)
Cite Us!