p-Smad2,3:Smad4:Foxh1 binds Activin Response Element

Stable Identifier
R-MMU-9717136
Type
Reaction [binding]
Species
Mus musculus
Compartment
ReviewStatus
5/5
General
SVG |   | PPTX  | SBGN
p-Smad2,3:Smad4:Foxh1 binds Activin Response Element
Smad2 and Smad3 do not bind DNA efficiently. They must interact with DNA-binding proteins to activate transcription. Foxh1 interacts with phospho-Smad2 and phospho-Smad3 complexed with Smad4 at promoters containing the Activin Response Element (Labbe et al. 1998, Weisberg et al. 1998, Liu et al. 1999, Izzi et al. 2007).
Literature References
PubMed ID Title Journal Year
17568773 Foxh1 recruits Gsc to negatively regulate Mixl1 expression during early mouse development

Wrana, JL, Izzi, L, Labbé, E, Zakin, L, Silvestri, C, Attisano, L, von Both, I

EMBO J 2007
9858566 FAST-2 is a mammalian winged-helix protein which mediates transforming growth factor beta signals

Prabhu, L, Dou, CL, Lai, E, Liu, B

Mol Cell Biol 1999
9702197 Smad2 and Smad3 positively and negatively regulate TGF beta-dependent transcription through the forkhead DNA-binding protein FAST2

Wrana, JL, Labbé, E, Silvestri, C, Attisano, L, Hoodless, PA

Mol Cell 1998
10349617 A mouse homologue of FAST-1 transduces TGF beta superfamily signals and is expressed during early embryogenesis

Hogan, BL, Weisberg, E, Whitman, M, Farnsworth, CL, Chen, X, Winnier, GE

Mech Dev 1998
Participants
This event is regulated
Orthologous Events
Authored
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