Reactome | Asb6 [cytosol]

Asb6 [cytosol]

Stable Identifier

R-MMU-975412

Type

Protein [EntityWithAccessionedSequence]

Species

Mus musculus

Compartment

cytosol

Synonyms

ASB6, Q91ZU1

Locations in the PathwayBrowser

Expand all

Immune System (Mus musculus)

- Adaptive Immune System (Mus musculus)
  - Class I MHC mediated antigen processing & presentation (Mus musculus)
    - Antigen processing: Ubiquitination & Proteasome degradation (Mus musculus)
      - Interaction of E3 with substrate and E2-Ub complex (Mus musculus)
        
        Ag-substrate:E3:E2:Ub [cytosol] (Mus musculus)
        
        E3 ligases in proteasomal degradation [cytosol] (Mus musculus)
        
        RNF7 (RBX2):CUL5:EloB/C:ASB [cytosol] (Mus musculus)
        
        ASB family [cytosol] (Mus musculus)
        
        Asb6 [cytosol] (Mus musculus)
        
        E3 ligases in proteasomal degradation [cytosol] (Mus musculus)
        
        RNF7 (RBX2):CUL5:EloB/C:ASB [cytosol] (Mus musculus)
        
        ASB family [cytosol] (Mus musculus)
        
        Asb6 [cytosol] (Mus musculus)
      - Polyubiquitination of substrate (Mus musculus)
        
        E3 ligases in proteasomal degradation [cytosol] (Mus musculus)
        
        RNF7 (RBX2):CUL5:EloB/C:ASB [cytosol] (Mus musculus)
        
        ASB family [cytosol] (Mus musculus)
        
        Asb6 [cytosol] (Mus musculus)
        
        E3:K48-polyubiquitinated substrate [cytosol] (Mus musculus)
        
        E3 ligases in proteasomal degradation [cytosol] (Mus musculus)
        
        RNF7 (RBX2):CUL5:EloB/C:ASB [cytosol] (Mus musculus)
        
        ASB family [cytosol] (Mus musculus)
        
        Asb6 [cytosol] (Mus musculus)
        
        E3:Ub:substrate [cytosol] (Mus musculus)
        
        E3 ligases in proteasomal degradation [cytosol] (Mus musculus)
        
        RNF7 (RBX2):CUL5:EloB/C:ASB [cytosol] (Mus musculus)
        
        ASB family [cytosol] (Mus musculus)
        
        Asb6 [cytosol] (Mus musculus)
      - Release of E3 from polyubiquitinated substrate (Mus musculus)
        
        E3 ligases in proteasomal degradation [cytosol] (Mus musculus)
        
        RNF7 (RBX2):CUL5:EloB/C:ASB [cytosol] (Mus musculus)
        
        ASB family [cytosol] (Mus musculus)
        
        Asb6 [cytosol] (Mus musculus)
        
        E3:K48-polyubiquitinated substrate [cytosol] (Mus musculus)
        
        E3 ligases in proteasomal degradation [cytosol] (Mus musculus)
        
        RNF7 (RBX2):CUL5:EloB/C:ASB [cytosol] (Mus musculus)
        
        ASB family [cytosol] (Mus musculus)
        
        Asb6 [cytosol] (Mus musculus)
      - Transfer of Ub from E2 to substrate and release of E2 (Mus musculus)
        
        Ag-substrate:E3:E2:Ub [cytosol] (Mus musculus)
        
        E3 ligases in proteasomal degradation [cytosol] (Mus musculus)
        
        RNF7 (RBX2):CUL5:EloB/C:ASB [cytosol] (Mus musculus)
        
        ASB family [cytosol] (Mus musculus)
        
        Asb6 [cytosol] (Mus musculus)
        
        E3 ligases in proteasomal degradation [cytosol] (Mus musculus)
        
        RNF7 (RBX2):CUL5:EloB/C:ASB [cytosol] (Mus musculus)
        
        ASB family [cytosol] (Mus musculus)
        
        Asb6 [cytosol] (Mus musculus)
        
        E3:Ub:substrate [cytosol] (Mus musculus)
        
        E3 ligases in proteasomal degradation [cytosol] (Mus musculus)
        
        RNF7 (RBX2):CUL5:EloB/C:ASB [cytosol] (Mus musculus)
        
        ASB family [cytosol] (Mus musculus)
        
        Asb6 [cytosol] (Mus musculus)

Metabolism of proteins (Mus musculus)

- Post-translational protein modification (Mus musculus)
  - Neddylation (Mus musculus)
    - AcM-UBE2F transfers NEDD8 to CRL5 E3 ubiquitin ligase complex (Mus musculus)
      - NEDD8-AcM-UBE2F:CRL5 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Mus musculus)
        
        CRL5 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Mus musculus)
        
        CRL5 E3 ubiquitin ligase [cytosol] (Mus musculus)
        
        CUL5-box protein [cytosol] (Mus musculus)
        
        Asb6 [cytosol] (Mus musculus)
      - NEDD8-CRL5 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Mus musculus)
        
        NEDD8-CRL5 E3 ligase [cytosol] (Mus musculus)
        
        CUL5-box protein [cytosol] (Mus musculus)
        
        Asb6 [cytosol] (Mus musculus)
    - CAND1 binds cytosolic CRL E3 ubiquitin ligases (Mus musculus)
      - CRL E3 ubiquitin ligase:CAND1 [cytosol] (Mus musculus)
        
        CRL E3 ubiquitin ligases [cytosol] (Mus musculus)
        
        CRL5 E3 ubiquitin ligase [cytosol] (Mus musculus)
        
        CUL5-box protein [cytosol] (Mus musculus)
        
        Asb6 [cytosol] (Mus musculus)
      - CRL E3 ubiquitin ligases [cytosol] (Mus musculus)
        
        CRL5 E3 ubiquitin ligase [cytosol] (Mus musculus)
        
        CUL5-box protein [cytosol] (Mus musculus)
        
        Asb6 [cytosol] (Mus musculus)
    - COMMDs displace CAND1 from cytosolic CRL E3 ubiquitin ligase complexes (Mus musculus)
      - CRL E3 ubiquitin ligase:CAND1 [cytosol] (Mus musculus)
        
        CRL E3 ubiquitin ligases [cytosol] (Mus musculus)
        
        CRL5 E3 ubiquitin ligase [cytosol] (Mus musculus)
        
        CUL5-box protein [cytosol] (Mus musculus)
        
        Asb6 [cytosol] (Mus musculus)
      - CRL E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Mus musculus)
        
        CRL5 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Mus musculus)
        
        CRL5 E3 ubiquitin ligase [cytosol] (Mus musculus)
        
        CUL5-box protein [cytosol] (Mus musculus)
        
        Asb6 [cytosol] (Mus musculus)
    - COP9 signalosome deneddylates cytosolic CRL E3 ubiquitin ligase complexes (Mus musculus)
      - CRL E3 ubiquitin ligase complex:COMMDs:CCDC22:DCUN1Ds [cytosol] (Mus musculus)
        
        CRL5 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Mus musculus)
        
        CRL5 E3 ubiquitin ligase [cytosol] (Mus musculus)
        
        CUL5-box protein [cytosol] (Mus musculus)
        
        Asb6 [cytosol] (Mus musculus)
      - NEDD8 CRL E3 ubiquitin ligases:COMMDs:CCDC22:DCUN1Ds [cytosol] (Mus musculus)
        
        NEDD8-CRL5 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Mus musculus)
        
        NEDD8-CRL5 E3 ligase [cytosol] (Mus musculus)
        
        CUL5-box protein [cytosol] (Mus musculus)
        
        Asb6 [cytosol] (Mus musculus)
    - NEDD8:AcM-UBE2F binds CRL5 E3 ubiquitin ligase complex (Mus musculus)
      - CRL5 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Mus musculus)
        
        CRL5 E3 ubiquitin ligase [cytosol] (Mus musculus)
        
        CUL5-box protein [cytosol] (Mus musculus)
        
        Asb6 [cytosol] (Mus musculus)
      - NEDD8-AcM-UBE2F:CRL5 E3 ubiquitin ligase:COMMDs:CCDC22:DCUN1Ds [cytosol] (Mus musculus)
        
        CRL5 E3 ubiquitin ligase:COMMDs:CCDC22 [cytosol] (Mus musculus)
        
        CRL5 E3 ubiquitin ligase [cytosol] (Mus musculus)
        
        CUL5-box protein [cytosol] (Mus musculus)
        
        Asb6 [cytosol] (Mus musculus)

External Reference Information

External Reference

UniProt:Q91ZU1

Gene Names

Asb6

Reference Genes

BioGPS Gene:72323 Asb6

ENSEMBL:ENSMUSG00000039483

ENSEMBL:ENSMUSG00000039483.11 Asb6

KEGG Gene (Mus musculus):72323 Asb6

Monarch:72323 Asb6

NCBI Gene:72323 Asb6

UCSC:Q91ZU1 Asb6

Reference Transcript

RefSeq:NM_133346.2 Asb6

Other Identifiers

10481508

1448431_at

160748_at

166040_f_at

17383699

4341226

4411948

4488665

4524226

5080338

5347147

5349865

5472823

5519790

72323

AA409356_rc_s_at

A_51_P478610

GE39518

GO:0003674

GO:0005515

GO:0005737

GO:0016567

GO:0023052

GO:0035556

GO:0036211

ILMN_1252320

ILMN_1254737

mMC018913

Participates

as a member of

Inferred From

ASB6 [cytosol] (Homo sapiens)

Cross References

RefSeq

NP_579924.1

Ensembl

ENSMUST00000041726, ENSMUSP00000043462, ENSMUSG00000039483

PRO

Q91ZU1

MGI

1919573

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