Expression of Eomes in the primitive streak

Stable Identifier
R-MMU-9754479
Type
Reaction [omitted]
Species
Mus musculus
Compartment
nucleoplasm
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Expression of Eomes in the primitive streak
Eomesodermin (Eomes) is expressed in cells of the proximal posterior epiblast prior to formation of the primitive streak and gastrulation (Ciruna and Rossant 1999, Arnold et al. 2008, Simon et al. 2017). During the first day of gastrulation, Eomes is expressed in the posterior epiblast, in the primitive streak, and in all cells leaving the primitive streak, both mesoderm and endoderm (Probst et al. 2021). Though Eomes is required for exit from pluripotency and formation of mesoderm and endoderm (Russ et al. 2000, Tosic et al. 2019), Eomes-expressing cells are present in anterior mesoderm derivatives and are excluded from posterior mesoderm derivatives (Ciruna and Rossant 1999, Costello et al. 2011).
Literature References
PubMed ID Title Journal Year
21822279 The T-box transcription factor Eomesodermin acts upstream of Mesp1 to specify cardiac mesoderm during mouse gastrulation

Bikoff, EK, Costello, I, Pimeisl, IM, Dräger, S, Arnold, SJ, Robertson, EJ

Nat Cell Biol 2011
31792383 Eomes and Brachyury control pluripotency exit and germ-layer segregation by changing the chromatin state

Köttgen, M, Barg, M, Kim, GJ, Pavlovic, M, Hein, L, Hofherr, A, Mersiowsky, SL, Probst, S, Tosic, J, Arnold, SJ, Schröder, CM

Nat Cell Biol 2019
10330500 Expression of the T-box gene Eomesodermin during early mouse development

Rossant, J, Ciruna, BG

Mech Dev 1999
28174238 Functional characterisation of cis-regulatory elements governing dynamic Eomes expression in the early mouse embryo

Bikoff, EK, Costello, I, Simon, CS, Hughes, JR, Higgs, DR, Downes, DJ, Telenius, J, Robertson, EJ, Gosden, ME

Development 2017
10716450 Eomesodermin is required for mouse trophoblast development and mesoderm formation

Pearce, JJ, Nehls, MC, Russ, AP, Carlton, MB, Aparicio, SA, Evans, MJ, Surani, MA, Colledge, WH, Ryan, K, Wilson, V, Barton, SC, Wattler, S

Nature 2000
33199445 Spatiotemporal sequence of mesoderm and endoderm lineage segregation during mouse gastrulation

Grün, D, Schwan, C, Probst, S, Tosic, J, Arnold, SJ, Sagar, S

Development 2021
18171685 Pivotal roles for eomesodermin during axis formation, epithelium-to-mesenchyme transition and endoderm specification in the mouse

Bikoff, EK, Hofmann, UK, Arnold, SJ, Robertson, EJ

Development 2008
Participants
Input
Output
This event is regulated
Positively by
Regulator
p-2S-Smad2,3:Smad4:Foxh1:Smad3:Eomes gene [nucleoplasm] (Mus musculus)
Orthologous Events
Expression of EOMES in the primitive streak (Homo sapiens)
Authored
May, B  (2021-09-23)
Reviewed
Tam, PPL  (2022-05-08)
Probst, S  (2022-07-18)
Salehin, N  (2022-05-08)
Zissel, L  (2022-07-18)
Created
May, B  (2021-09-28)
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