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Skp2 [nucleoplasm]
Stable Identifier
R-MMU-975554
Type
Protein [EntityWithAccessionedSequence]
Species
Mus musculus
Compartment
nucleoplasm
Synonyms
SKP2, Q9Z0Z3
Locations in the PathwayBrowser
Expand all
Cell Cycle (Mus musculus)
Cell Cycle, Mitotic (Mus musculus)
Mitotic G1 phase and G1/S transition (Mus musculus)
G1 Phase (Mus musculus)
Cyclin D associated events in G1 (Mus musculus)
Phosphorylated p130 (RBL2) binds SCF(Skp2):Cks1 complex (Mus musculus)
CUL1:SKP1:SKP2:CKS1B [nucleoplasm] (Mus musculus)
CUL1:SKP1:SKP2 [nucleoplasm] (Mus musculus)
Skp2 [nucleoplasm] (Mus musculus)
p-T401,S672,1035-RBL2:SCF(Skp2):Cks1 [nucleoplasm] (Mus musculus)
CUL1:SKP1:SKP2:CKS1B [nucleoplasm] (Mus musculus)
CUL1:SKP1:SKP2 [nucleoplasm] (Mus musculus)
Skp2 [nucleoplasm] (Mus musculus)
Ubiquitination of p130 (RBL2) by SCF (Skp2) (Mus musculus)
CUL1:SKP1:SKP2:CKS1B [nucleoplasm] (Mus musculus)
CUL1:SKP1:SKP2 [nucleoplasm] (Mus musculus)
Skp2 [nucleoplasm] (Mus musculus)
p-T401,S672,1035-RBL2:SCF(Skp2):Cks1 [nucleoplasm] (Mus musculus)
CUL1:SKP1:SKP2:CKS1B [nucleoplasm] (Mus musculus)
CUL1:SKP1:SKP2 [nucleoplasm] (Mus musculus)
Skp2 [nucleoplasm] (Mus musculus)
G1/S Transition (Mus musculus)
Cyclin E associated events during G1/S transition (Mus musculus)
SCF(Skp2)-mediated degradation of p27/p21 (Mus musculus)
Association of Cks1 with SCF(Skp2) complex (Mus musculus)
CUL1:SKP1:SKP2 [nucleoplasm] (Mus musculus)
Skp2 [nucleoplasm] (Mus musculus)
CUL1:SKP1:SKP2:CKS1B [nucleoplasm] (Mus musculus)
CUL1:SKP1:SKP2 [nucleoplasm] (Mus musculus)
Skp2 [nucleoplasm] (Mus musculus)
Binding of phospho-p27/p21:Cdk2:Cyclin E/A to the SCF(Skp2):Cks1 complex (Mus musculus)
CUL1:SKP1:SKP2:CKS1B [nucleoplasm] (Mus musculus)
CUL1:SKP1:SKP2 [nucleoplasm] (Mus musculus)
Skp2 [nucleoplasm] (Mus musculus)
Cyclin E/A:CDK2:p-S130-CDKN1A,p-T187-CDKN1B:CUL1:SKP1:SKP2:CKS1B [nucleoplasm] (Mus musculus)
CUL1:SKP1:SKP2:CKS1B [nucleoplasm] (Mus musculus)
CUL1:SKP1:SKP2 [nucleoplasm] (Mus musculus)
Skp2 [nucleoplasm] (Mus musculus)
Degradation of ubiquitinated p27/p21 by the 26S proteasome (Mus musculus)
CUL1:SKP1:SKP2:CKS1B [nucleoplasm] (Mus musculus)
CUL1:SKP1:SKP2 [nucleoplasm] (Mus musculus)
Skp2 [nucleoplasm] (Mus musculus)
Cyclin E/A:CDK2:p-S130-CDKN1A,p-T187-CDKN1B:CUL1:SKP1:SKP2:CKS1B:3xubiquitin [nucleoplasm] (Mus musculus)
Cyclin E/A:CDK2:p-S130-CDKN1A,p-T187-CDKN1B:CUL1:SKP1:SKP2:CKS1B [nucleoplasm] (Mus musculus)
CUL1:SKP1:SKP2:CKS1B [nucleoplasm] (Mus musculus)
CUL1:SKP1:SKP2 [nucleoplasm] (Mus musculus)
Skp2 [nucleoplasm] (Mus musculus)
Ubiquitination of phospho-p27/p21 (Mus musculus)
CUL1:SKP1:SKP2:CKS1B [nucleoplasm] (Mus musculus)
CUL1:SKP1:SKP2 [nucleoplasm] (Mus musculus)
Skp2 [nucleoplasm] (Mus musculus)
Cyclin E/A:CDK2:p-S130-CDKN1A,p-T187-CDKN1B:CUL1:SKP1:SKP2:CKS1B [nucleoplasm] (Mus musculus)
CUL1:SKP1:SKP2:CKS1B [nucleoplasm] (Mus musculus)
CUL1:SKP1:SKP2 [nucleoplasm] (Mus musculus)
Skp2 [nucleoplasm] (Mus musculus)
Cyclin E/A:CDK2:p-S130-CDKN1A,p-T187-CDKN1B:CUL1:SKP1:SKP2:CKS1B:3xubiquitin [nucleoplasm] (Mus musculus)
Cyclin E/A:CDK2:p-S130-CDKN1A,p-T187-CDKN1B:CUL1:SKP1:SKP2:CKS1B [nucleoplasm] (Mus musculus)
CUL1:SKP1:SKP2:CKS1B [nucleoplasm] (Mus musculus)
CUL1:SKP1:SKP2 [nucleoplasm] (Mus musculus)
Skp2 [nucleoplasm] (Mus musculus)
Regulation of mitotic cell cycle (Mus musculus)
APC/C-mediated degradation of cell cycle proteins (Mus musculus)
APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 (Mus musculus)
APC/C:Cdh1 polyubiquitinates SKP2 (Mus musculus)
RB1:SKP2:APC/C:Cdh1 [nucleoplasm] (Mus musculus)
Skp2 [nucleoplasm] (Mus musculus)
RB1 recruits APC/C:Cdh1 complex to SKP2 (Mus musculus)
RB1:SKP2:APC/C:Cdh1 [nucleoplasm] (Mus musculus)
Skp2 [nucleoplasm] (Mus musculus)
Skp2 [nucleoplasm] (Mus musculus)
S Phase (Mus musculus)
Cyclin A:Cdk2-associated events at S phase entry (Mus musculus)
SCF(Skp2)-mediated degradation of p27/p21 (Mus musculus)
Association of Cks1 with SCF(Skp2) complex (Mus musculus)
CUL1:SKP1:SKP2 [nucleoplasm] (Mus musculus)
Skp2 [nucleoplasm] (Mus musculus)
CUL1:SKP1:SKP2:CKS1B [nucleoplasm] (Mus musculus)
CUL1:SKP1:SKP2 [nucleoplasm] (Mus musculus)
Skp2 [nucleoplasm] (Mus musculus)
Binding of phospho-p27/p21:Cdk2:Cyclin E/A to the SCF(Skp2):Cks1 complex (Mus musculus)
CUL1:SKP1:SKP2:CKS1B [nucleoplasm] (Mus musculus)
CUL1:SKP1:SKP2 [nucleoplasm] (Mus musculus)
Skp2 [nucleoplasm] (Mus musculus)
Cyclin E/A:CDK2:p-S130-CDKN1A,p-T187-CDKN1B:CUL1:SKP1:SKP2:CKS1B [nucleoplasm] (Mus musculus)
CUL1:SKP1:SKP2:CKS1B [nucleoplasm] (Mus musculus)
CUL1:SKP1:SKP2 [nucleoplasm] (Mus musculus)
Skp2 [nucleoplasm] (Mus musculus)
Degradation of ubiquitinated p27/p21 by the 26S proteasome (Mus musculus)
CUL1:SKP1:SKP2:CKS1B [nucleoplasm] (Mus musculus)
CUL1:SKP1:SKP2 [nucleoplasm] (Mus musculus)
Skp2 [nucleoplasm] (Mus musculus)
Cyclin E/A:CDK2:p-S130-CDKN1A,p-T187-CDKN1B:CUL1:SKP1:SKP2:CKS1B:3xubiquitin [nucleoplasm] (Mus musculus)
Cyclin E/A:CDK2:p-S130-CDKN1A,p-T187-CDKN1B:CUL1:SKP1:SKP2:CKS1B [nucleoplasm] (Mus musculus)
CUL1:SKP1:SKP2:CKS1B [nucleoplasm] (Mus musculus)
CUL1:SKP1:SKP2 [nucleoplasm] (Mus musculus)
Skp2 [nucleoplasm] (Mus musculus)
Ubiquitination of phospho-p27/p21 (Mus musculus)
CUL1:SKP1:SKP2:CKS1B [nucleoplasm] (Mus musculus)
CUL1:SKP1:SKP2 [nucleoplasm] (Mus musculus)
Skp2 [nucleoplasm] (Mus musculus)
Cyclin E/A:CDK2:p-S130-CDKN1A,p-T187-CDKN1B:CUL1:SKP1:SKP2:CKS1B [nucleoplasm] (Mus musculus)
CUL1:SKP1:SKP2:CKS1B [nucleoplasm] (Mus musculus)
CUL1:SKP1:SKP2 [nucleoplasm] (Mus musculus)
Skp2 [nucleoplasm] (Mus musculus)
Cyclin E/A:CDK2:p-S130-CDKN1A,p-T187-CDKN1B:CUL1:SKP1:SKP2:CKS1B:3xubiquitin [nucleoplasm] (Mus musculus)
Cyclin E/A:CDK2:p-S130-CDKN1A,p-T187-CDKN1B:CUL1:SKP1:SKP2:CKS1B [nucleoplasm] (Mus musculus)
CUL1:SKP1:SKP2:CKS1B [nucleoplasm] (Mus musculus)
CUL1:SKP1:SKP2 [nucleoplasm] (Mus musculus)
Skp2 [nucleoplasm] (Mus musculus)
Synthesis of DNA (Mus musculus)
Switching of origins to a post-replicative state (Mus musculus)
Orc1 removal from chromatin (Mus musculus)
Phosphorylated Orc1 is ubiquitinated while still associated with chromatin (Mus musculus)
SCF (SKP2) complex [nucleoplasm] (Mus musculus)
Skp2 [nucleoplasm] (Mus musculus)
Cellular responses to stimuli (Mus musculus)
Cellular responses to stress (Mus musculus)
Cellular response to chemical stress (Mus musculus)
KEAP1-NFE2L2 pathway (Mus musculus)
Regulation of BACH1 activity (Mus musculus)
BACH1:FBXL17 binds SCF(SKP2) complex (Mus musculus)
BACH1:FBXL17:SCF (SKP2) [nucleoplasm] (Mus musculus)
SCF (SKP2) complex [nucleoplasm] (Mus musculus)
Skp2 [nucleoplasm] (Mus musculus)
SCF (SKP2) complex [nucleoplasm] (Mus musculus)
Skp2 [nucleoplasm] (Mus musculus)
FBXL17 ubiquitinates BACH1 (in BACH1:FBXL17:SCF (SKP2)) (Mus musculus)
BACH1:FBXL17:SCF (SKP2) [nucleoplasm] (Mus musculus)
SCF (SKP2) complex [nucleoplasm] (Mus musculus)
Skp2 [nucleoplasm] (Mus musculus)
SCF (SKP2) complex [nucleoplasm] (Mus musculus)
Skp2 [nucleoplasm] (Mus musculus)
DNA Replication (Mus musculus)
Synthesis of DNA (Mus musculus)
Switching of origins to a post-replicative state (Mus musculus)
Orc1 removal from chromatin (Mus musculus)
Phosphorylated Orc1 is ubiquitinated while still associated with chromatin (Mus musculus)
SCF (SKP2) complex [nucleoplasm] (Mus musculus)
Skp2 [nucleoplasm] (Mus musculus)
Gene expression (Transcription) (Mus musculus)
RNA Polymerase II Transcription (Mus musculus)
Generic Transcription Pathway (Mus musculus)
Transcriptional regulation by RUNX2 (Mus musculus)
Regulation of RUNX2 expression and activity (Mus musculus)
SCF(SKP2) complex binds RUNX2 (Mus musculus)
RUNX2:SCF(SKP2) [nucleoplasm] (Mus musculus)
SCF (SKP2) complex [nucleoplasm] (Mus musculus)
Skp2 [nucleoplasm] (Mus musculus)
SCF (SKP2) complex [nucleoplasm] (Mus musculus)
Skp2 [nucleoplasm] (Mus musculus)
SCF(SKP2) polyubiquitinates RUNX2 (Mus musculus)
RUNX2:SCF(SKP2) [nucleoplasm] (Mus musculus)
SCF (SKP2) complex [nucleoplasm] (Mus musculus)
Skp2 [nucleoplasm] (Mus musculus)
SCF (SKP2) complex [nucleoplasm] (Mus musculus)
Skp2 [nucleoplasm] (Mus musculus)
Metabolism of proteins (Mus musculus)
Post-translational protein modification (Mus musculus)
Deubiquitination (Mus musculus)
Ub-specific processing proteases (Mus musculus)
USP13 binds UFD1L:SKP2 (Mus musculus)
UFD1L:SKP2 [nucleoplasm] (Mus musculus)
Skp2 [nucleoplasm] (Mus musculus)
USP13:UFD1L:SKP2 [nucleoplasm] (Mus musculus)
UFD1L:SKP2 [nucleoplasm] (Mus musculus)
Skp2 [nucleoplasm] (Mus musculus)
External Reference Information
External Reference
UniProt:Q9Z0Z3
Gene Names
Skp2
Reference Genes
BioGPS Gene:27401 Skp2
ENSEMBL:ENSMUSG00000054115
KEGG:mmu:27401 Skp2
Monarch:27401 Skp2
NCBI Gene:27401 Skp2
UCSC:Q9Z0Z3 Skp2
Reference Transcript
RefSeq:NM_013787.3 Skp2
Other Identifiers
10427606
111913_at
1418969_at
1425072_at
1436000_a_at
1437033_a_at
1449293_a_at
1460247_a_at
17315878
27401
4334072
4340784
4378214
4520105
4586563
4633979
4694433
4786147
4910323
4945073
4954374
4966605
4978164
5038192
5048390
5059413
5104472
5175961
5255823
5291737
5349720
5361464
5371775
5371892
5402201
5403804
5408240
5432051
5463060
5524794
5606680
A_52_P144954
A_55_P2716067
A_66_P134481
GO:0000082
GO:0000086
GO:0000209
GO:0002376
GO:0003824
GO:0005515
GO:0005634
GO:0005654
GO:0005730
GO:0005737
GO:0005829
GO:0006511
GO:0016301
GO:0016567
GO:0016740
GO:0019005
GO:0030163
GO:0031146
GO:0033148
GO:0042802
GO:0042981
GO:0043161
GO:0043226
GO:0045087
GO:0048661
GO:0051607
GO:0051726
GO:0060090
GO:0070534
GO:0070936
GO:0098542
GO:1902916
GO:1905168
GO:1990756
ILMN_1227281
ILMN_1243441
ILMN_1251616
ILMN_2592285
ILMN_2633697
ILMN_2663114
mMC021560
mMR027125
mMR030058
Participates
as a component of
UFD1L:SKP2 [nucleoplasm] (Mus musculus)
SCF (SKP2) complex [nucleoplasm] (Mus musculus)
RB1:SKP2:APC/C:Cdh1 [nucleoplasm] (Mus musculus)
CUL1:SKP1:SKP2 [nucleoplasm] (Mus musculus)
as an input of
RB1 recruits APC/C:Cdh1 complex to SKP2 (Mus musculus)
Other forms of this molecule
Skp2 [cytosol]
Skp2 [nucleoplasm]
Inferred From
SKP2 [nucleoplasm]
(Homo sapiens)
Cross References
RefSeq
NP_038815.1
ENSEMBL
ENSMUSP00000094225
,
ENSMUSP00000106215
,
ENSMUSG00000054115
,
ENSMUST00000110585
,
ENSMUST00000096482
PRO
Q9Z0Z3
MGI
1351663
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