Eomes and Tbxt bind the Sox2 gene

Stable Identifier
R-MMU-9756665
Type
Reaction [binding]
Species
Mus musculus
Compartment
nucleoplasm
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Eomes and Tbxt bind the Sox2 gene
Eomes and Tbxt positively regulate the exit from pluripotency by binding and repressing the expression of Sox2, a gene that maintains pluripotency (Tosic et al. 2019).
Literature References
PubMed ID Title Journal Year
31792383 Eomes and Brachyury control pluripotency exit and germ-layer segregation by changing the chromatin state

Köttgen, M, Barg, M, Kim, GJ, Pavlovic, M, Hein, L, Hofherr, A, Mersiowsky, SL, Probst, S, Tosic, J, Arnold, SJ, Schröder, CM

Nat Cell Biol 2019
Participants
Input
Output
Orthologous Events
EOMES and TBXT bind the SOX2 gene (Homo sapiens)
Authored
May, B  (2021-10-14)
Reviewed
Tam, PPL  (2022-05-08)
Probst, S  (2022-07-18)
Salehin, N  (2022-05-08)
Zissel, L  (2022-07-18)
Created
May, B  (2021-10-16)
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