Expression of Mixl1 in the primitive streak

Stable Identifier
R-MMU-9758506
Type
Reaction [omitted]
Species
Mus musculus
Compartment
ReviewStatus
5/5
General
SVG |   | PPTX  | SBGN
Expression of Mixl1 in the primitive streak
During gastrulation, Mixl1 is expressed throughout the primitive streak, and the nascent mesoderm, but then becomes localized to the anterior and posterior ends of the streak at E7.5 (Pearce and Evans 1999, Robb et al. 2000, Wolfe and Downes 2014). Transcription of Mixl1 is activated by Nodal via Smad2 and Smad3 and by Eomes (Teo et al. 2011, Xi et al. 2011, Aragon et al. 2019, Tosic et al. 2019).
Literature References
PubMed ID Title Journal Year
11084649 Cloning, expression analysis, and chromosomal localization of murine and human homologues of a Xenopus mix gene

Copeland, NG, Robb, L, Brodnicki, TC, Gilbert, DJ, Jenkins, NA, Begley, CG, Elefanty, AG, Hartley, L

Dev Dyn 2000
24632399 Mixl1 localizes to putative axial stem cell reservoirs and their posterior descendants in the mouse embryo

Wolfe, AD, Downs, KM

Gene Expr Patterns 2014
10495285 Mml, a mouse Mix-like gene expressed in the primitive streak

Pearce, JJ, Evans, MJ

Mech Dev 1999
33199445 Spatiotemporal sequence of mesoderm and endoderm lineage segregation during mouse gastrulation

Grün, D, Schwan, C, Probst, S, Tosic, J, Arnold, SJ, Sagar, S

Development 2021
21245162 Pluripotency factors regulate definitive endoderm specification through eomesodermin

Dunn, NR, Chng, Z, Trotter, MW, Vallier, L, Teo, AK, Ang, LT, Brown, S, Arnold, SJ, Robertson, EJ

Genes Dev. 2011
31582430 Structural basis for distinct roles of SMAD2 and SMAD3 in FOXH1 pioneer-directed TGF-β signaling

Tian, L, Macias, MJ, Hu, J, Zou, Y, Shu, W, Massagué, J, Aragón, E, Wang, Q, Hadjantonakis, AK, Su, J, Gomes, T, Agrawal, S, Kaczmarska, Z, Torner, C, Márquez, JA, Ruiz, L, Morgani, SM

Genes Dev 2019
22196728 A poised chromatin platform for TGF-β access to master regulators

Liu, JX, Zaromytidou, AI, Chow-Tsang, LF, Mark, W, Kaartinen, V, Barlas, A, Massagué, J, Manova-Todorova, K, Wang, Z, Studer, L, Zhang, XH, Xi, Q, Patel, DJ, Kim, H

Cell 2011
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