Expression of Foxf1 in lateral plate mesoderm

Stable Identifier
R-MMU-9759844
Type
Reaction [omitted]
Species
Mus musculus
Compartment
nucleoplasm
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Expression of Foxf1 in lateral plate mesoderm
The Foxf1 gene is transcribed to yield mRNA and the mRNA is translated to yield Foxf1 protein. Foxf1 is a transcription factor expressed in extraembryonic mesoderm and lateral plate mesoderm (Peterson et al. 1997, Mahlapuu et al. 2001, Kalinichenko et al. 2003, Ormestad et al. 2004, Fleury et al. 2015). Hedgehog proteins Shh and Ihh produced in the primitive endoderm (hypoblast) (Becker et al. 1997) activate expression of Foxf1 in the lateral plate mesoderm and extraembryonic mesoderm (Rojas et al. 2005, Astorga and Carlsson 2007). Hedgehog activation of Foxf1 in the lateral plate mesoderm requires Smoothened (Smo, Astorga and Carlsson 2007) and may occur via Gli factors that bind the enhancer of Foxf1 (Hoffman et al. 2014).
Literature References
PubMed ID Title Journal Year
12711542 The forkhead box F1 transcription factor is expressed in brain and head mesenchyme during mouse embryonic development

Kalinichenko, VV, Gusarova, GA, Shin, B, Costa, RH

Gene Expr Patterns 2003
15987774 Gata4 expression in lateral mesoderm is downstream of BMP4 and is activated directly by Forkhead and GATA transcription factors through a distal enhancer element

Rojas, A, De Val, S, Heidt, AB, Xu, SM, Bristow, J, Black, BL

Development 2005
17881493 Hedgehog induction of murine vasculogenesis is mediated by Foxf1 and Bmp4

Astorga, J, Carlsson, P

Development 2007
14745957 Differences in the embryonic expression patterns of mouse Foxf1 and -2 match their distinct mutant phenotypes

Ormestad, M, Astorga, J, Carlsson, P

Dev Dyn 2004
26293303 FOXF1 inhibits hematopoietic lineage commitment during early mesoderm specification

Fleury, M, Eliades, A, Carlsson, P, Lacaud, G, Kouskoff, V

Development 2015
11124112 The forkhead transcription factor Foxf1 is required for differentiation of extra-embryonic and lateral plate mesoderm

Mahlapuu, M, Ormestad, M, Enerbäck, S, Carlsson, P

Development 2001
11493558 Haploinsufficiency of the forkhead gene Foxf1, a target for sonic hedgehog signaling, causes lung and foregut malformations

Mahlapuu, M, Enerbäck, S, Carlsson, P

Development 2001
9486531 The winged helix transcriptional activator HFH-8 is expressed in the mesoderm of the primitive streak stage of mouse embryos and its cellular derivatives

Peterson, RS, Lim, L, Ye, H, Zhou, H, Overdier, DG, Costa, RH

Mech Dev 1997
Participants
Input
Output
This event is regulated
Positively by
Regulator
Ihh [extracellular region] (Mus musculus)
Regulator
Shh(34-?) [extracellular region] (Mus musculus)
Orthologous Events
Expression of FOXF1 in lateral plate mesoderm (Homo sapiens)
Authored
May, B  (2021-12-14)
Reviewed
Mosimann, C  (2022-11-09)
Prummel, KD  (2022-11-09)
Created
May, B  (2021-12-14)
Cite Us!