Sox10 binds Cdh19 gene promoter

Stable Identifier
R-MMU-9773193
Type
Reaction [binding]
Species
Mus musculus
Compartment
nucleoplasm
ReviewStatus
5/5
General
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Sox10 binds Cdh19 gene promoter
In mouse, the transcription factor Sox10, essential for migration of neural crest cells during formation of the enteric nervous system, binds Cdh19 gene promoter and stimulates Cdh19 transcription. Cdh19 knockdown results in retarded sacral migration of neural crest cells, while re-expression of Cdh19 partially rescues retarded migration of Sox10-null neural crest cells (Huang et al. 2022). Binding of Sox10 to the Cdh19 gene promoter was also demonstrated in mouse melanocytes, but Cdh19 was not found to be differentially expressed in melanocytes upon Sox10 gene knockout (Fufa et al. 2015).
Literature References
PubMed ID Title Journal Year
26206884 Genomic analysis reveals distinct mechanisms and functional classes of SOX10-regulated genes in melanocytes

Bennett, DC, Gildea, DE, Mccallion, AS, Song, L, Sviderskaya, EV, Safi, A, Gorkin, DU, Levy, D, Crawford, GE, Pavan, WJ, Loftus, SK, Watkins-Chow, DE, Fufa, TD, Harris, ML

Hum Mol Genet 2015
34425092 Direct Interaction of Sox10 With Cadherin-19 Mediates Early Sacral Neural Crest Cell Migration: Implications for Enteric Nervous System Development Defects

Yi, C, Wang, L, Burns, AJ, Huang, T, Ngai, SM, Tam, PKH, Chan, WY, Wang, X, Hou, Y, Wang, C, Sun, X, Sham, MH

Gastroenterology 2022
Participants
Input
Output
Orthologous Events
SOX10 binds CDH19 gene promoter (Homo sapiens)
Authored
Orlic-Milacic, M  (2022-05-25)
Reviewed
Brasch, J  (2023-04-18)
Created
Orlic-Milacic, M  (2022-05-02)
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