Cdh19 gene expression is stimulated by Sox10

Stable Identifier
R-MMU-9773210
Type
Reaction [omitted]
Species
Mus musculus
Compartment
nucleoplasm, plasma membrane
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Cdh19 gene expression is stimulated by Sox10
In mouse, the transcription factor Sox10, essential for migration of neural crest cells during formation of the enteric nervous system, directly stimulates Cdh19 gene transcription. Cdh19 knockdown results in retarded sacral migration of neural crest cells, while re-expression of Cdh19 partially rescues retarded migration of Sox10-null neural crest cells (Huang et al. 2022). While binding of Sox10 to the Cdh19 gene promoter was also demonstrated in mouse melanocytes, Cdh19 was not found to be differentially expressed in melanocytes upon Sox10 gene knockout (Fufa et al. 2015).
Literature References
PubMed ID Title Journal Year
34425092 Direct Interaction of Sox10 With Cadherin-19 Mediates Early Sacral Neural Crest Cell Migration: Implications for Enteric Nervous System Development Defects

Yi, C, Wang, L, Burns, AJ, Huang, T, Ngai, SM, Tam, PKH, Chan, WY, Wang, X, Hou, Y, Wang, C, Sun, X, Sham, MH

Gastroenterology 2022
Participants
Input
Output
This event is regulated
Positively by
Regulator
Sox10:Cdh19 gene [nucleoplasm] (Mus musculus)
Active Unit
Sox10 [nucleoplasm]
Orthologous Events
CDH19 gene expression is stimulated by SOX10 (Homo sapiens)
Authored
Orlic-Milacic, M  (2022-05-25)
Reviewed
Brasch, J  (2023-04-18)
Created
Orlic-Milacic, M  (2022-05-02)
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