Expression of Foxa2 in the anterior primitive streak

Stable Identifier
R-MMU-9796221
Type
Reaction [omitted]
Species
Mus musculus
Compartment
nucleoplasm
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Expression of Foxa2 in the anterior primitive streak
Foxa2 is first expressed at the anterior end of the primitive streak and then persists in notochord and definitive endoderm (Ang et al. 1993, Sasaki and Hogan 1993, Monaghan et al. 1993, Ruiz et al. 1993, Besnard et al. 2004). The Foxa2 gene contains enhancers that activate and enhance expression in the node and notochord (Sasaki and Hogan 1996, Nishizaki et al. 2001). Nodal signaling activates Smad2, Smad3 which then interact with Foxh1 at the Foxa2 promoter to activate transcription of Foxa2 (Yamamoto et al. 2001, Hoodless et al. 2001). Tead proteins also bind the Foxa2 promoter and interact with Yap1 to enhance transcription (Sawada et al. 2005, Sawada et al. 2008). Foxa2 is required for formation of the node and notochord (Weinstein et al. 1994, Ang and Rossant 1994).
Literature References
PubMed ID Title Journal Year
9078367 Enhancer analysis of the mouse HNF-3 beta gene: regulatory elements for node/notochord and floor plate are independent and consist of multiple sub-elements

Sasaki, H, Hogan, BL

Genes Cells 1996
16207754 Tead proteins activate the Foxa2 enhancer in the node in cooperation with a second factor

Sawada, A, Nishizaki, Y, Sato, H, Yada, Y, Nakayama, R, Yamamoto, S, Nishioka, N, Kondoh, H, Sasaki, H

Development 2005
8069909 HNF-3 beta is essential for node and notochord formation in mouse development

Ang, SL, Rossant, J

Cell 1994
8155584 Sequential expression of HNF-3 beta and HNF-3 alpha by embryonic organizing centers: the dorsal lip/node, notochord and floor plate

Ruiz i Altaba, A, Prezioso, VR, Darnell, JE, Jessell, TM

Mech Dev 1993
15567715 Immunohistochemical localization of Foxa1 and Foxa2 in mouse embryos and adult tissues

Besnard, V, Wert, SE, Hull, WM, Whitsett, JA

Gene Expr Patterns 2004
11287181 Identification of essential sequence motifs in the node/notochord enhancer of Foxa2 (Hnf3beta) gene that are conserved across vertebrate species

Nishizaki, Y, Shimazu, K, Kondoh, H, Sasaki, H

Mech Dev 2001
11358869 FoxH1 (Fast) functions to specify the anterior primitive streak in the mouse

Hoodless, PA, Pye, M, Chazaud, C, Labbé, E, Attisano, L, Rossant, J, Wrana, JL

Genes Dev 2001
11358868 The transcription factor FoxH1 (FAST) mediates Nodal signaling during anterior-posterior patterning and node formation in the mouse

Yamamoto, M, Meno, C, Sakai, Y, Shiratori, H, Mochida, K, Ikawa, Y, Saijoh, Y, Hamada, H

Genes Dev 2001
18332127 Redundant roles of Tead1 and Tead2 in notochord development and the regulation of cell proliferation and survival

Sawada, A, Kiyonari, H, Ukita, K, Nishioka, N, Imuta, Y, Sasaki, H

Mol Cell Biol 2008
8187630 Postimplantation expression patterns indicate a role for the mouse forkhead/HNF-3 alpha, beta and gamma genes in determination of the definitive endoderm, chordamesoderm and neuroectoderm

Monaghan, AP, Kaestner, KH, Grau, E, Schutz, G

Development 1993
8375339 Differential expression of multiple fork head related genes during gastrulation and axial pattern formation in the mouse embryo

Sasaki, H, Hogan, BL

Development 1993
8306889 The formation and maintenance of the definitive endoderm lineage in the mouse: involvement of HNF3/forkhead proteins

Ang, SL, Wierda, A, Wong, D, Stevens, KA, Cascio, S, Rossant, J, Zaret, KS

Development 1993
Participants
Input
Output
This event is regulated
Positively by
Regulator
Tead2,Tead4:Yap1:Tbxt:Foxa2 gene [nucleoplasm] (Mus musculus)
Orthologous Events
Expression of FOXA2 in the anterior primitive streak (Homo sapiens)
Authored
May, B  (2022-08-08)
Reviewed
Sasaki, H  (2022-10-15)
Created
May, B  (2022-08-09)
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