Expression of Noto gene in axial mesoderm

Stable Identifier
R-MMU-9796302
Type
Reaction [omitted]
Species
Mus musculus
Compartment
nucleoplasm
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Expression of Noto gene in axial mesoderm
Expression of homeobox protein Noto is activated by Foxa2 and Tbxt (T, Brachyury) (Abdelkhalek et al. 2004, Alten et al. 2012), however, when Foxa2 and Foxa1 were knocked out later in development at stage E7.5, expression of Noto was relatively normal until stage E10.5 when expression of Noto was lost (Maier et al. 2013). Tead2:Yap and Lef1:Ctnnb1 or Tcf7:Ctnnb1 activate the Noto promoter in vitro but appear to be dispensable for activation in the node and notochord in vivo (Alten et al 2012). Noto represses paraxial mesoderm fate and maintains axial mesoderm fate (Yamanaka et al. 2007). Knockout of Noto in mice demonstrates that Noto regulates node morphogenesis, notochordal ciliagenesis, and left-right patterning (Beckers et al. 2007). Part of this regulation is accomplished by the activation of cilia-related genes in the node and posterior region of the notochord by Noto (Beckers et al. 2007).
Literature References
PubMed ID Title Journal Year
23383217 Foxa1 and Foxa2 are required for formation of the intervertebral discs

Maier, JA, Lo, Y, Harfe, BD

PLoS One 2013
23110100 A novel mammal-specific three partite enhancer element regulates node and notochord-specific Noto expression

Alten, L, Schuster-Gossler, K, Eichenlaub, MP, Wittbrodt, B, Wittbrodt, J, Gossler, A

PLoS One 2012
15231714 The mouse homeobox gene Not is required for caudal notochord development and affected by the truncate mutation

Abdelkhalek, HB, Beckers, A, Schuster-Gossler, K, Pavlova, MN, Burkhardt, H, Lickert, H, Rossant, J, Reinhardt, R, Schalkwyk, LC, Müller, I, Herrmann, BG, Ceolin, M, Rivera-Pomar, R, Gossler, A

Genes Dev 2004
15533813 Identification of the mammalian Not gene via a phylogenomic approach

Plouhinec, JL, Granier, C, Le Mentec, C, Lawson, KA, Sabéran-Djoneidi, D, Aghion, J, Shi, DL, Collignon, J, Mazan, S

Gene Expr Patterns 2004
Participants
Input
Output
This event is regulated
Positively by
Regulator
Lef1,Tcf7:Ctnnb1 [nucleoplasm] (Mus musculus)
Regulator
Foxa1 [nucleoplasm] (Mus musculus)
Regulator
Tead2:Yap1 [nucleoplasm] (Mus musculus)
Regulator
Foxa2 [nucleoplasm] (Mus musculus)
Regulator
Tbxt [nucleoplasm] (Mus musculus)
Orthologous Events
Expression of NOTO in axial mesoderm (Homo sapiens)
Authored
May, B  (2022-08-06)
Reviewed
Sasaki, H  (2022-10-15)
Created
May, B  (2022-08-09)
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