Expression of Shh in axial mesoderm

Stable Identifier
R-MMU-9815762
Type
Reaction [omitted]
Species
Mus musculus
Compartment
ReviewStatus
5/5
General
SVG |   | PPTX  | SBGN
Expression of Shh in axial mesoderm
Sonic hedgehog Shh is expressed in the notochord and in notochord-derived cells that contribute to the nuclei pulposi of the spinal chord (Peck et al. 2017). In the notochord Shh is activated by Foxa1 and Foxa2 (Ang and Rossant 1994, Harrelson et al. 2012, Maier et al. 2013). Shh secreted by the notochord patterns adjacent tissue, including floor plate, somitocoele, neural tube, and facial midline (Echelard et al. 1993, Sagai et al. 2019, Abrams and Reiter 2021, reviewed in Placzek and Furley 1996, Stemple 2005).
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