Reactome | Expression of Shh in axial mesoderm

Expression of Shh in axial mesoderm

Stable Identifier

R-MMU-9815762

Type

Reaction [omitted]

Species

Mus musculus

Compartment

nucleoplasm, endoplasmic reticulum lumen

ReviewStatus

5/5

General

SBML | | PDF

SVG | | PPTX | SBGN

Sonic hedgehog Shh is expressed in the notochord and in notochord-derived cells that contribute to the nuclei pulposi of the spinal chord (Peck et al. 2017). In the notochord Shh is activated by Foxa1 and Foxa2 (Ang and Rossant 1994, Harrelson et al. 2012, Maier et al. 2013). Shh secreted by the notochord patterns adjacent tissue, including floor plate, somitocoele, neural tube, and facial midline (Echelard et al. 1993, Sagai et al. 2019, Abrams and Reiter 2021, reviewed in Placzek and Furley 1996, Stemple 2005).

Literature References

PubMed ID	Title	Journal	Year
28874804	Whole Transcriptome Analysis of Notochord-Derived Cells during Embryonic Formation of the Nucleus Pulposus Peck, SH, McKee, KK, Tobias, JW, Malhotra, NR, Harfe, BD, Smith, LJ	Sci Rep	2017
8069909	HNF-3 beta is essential for node and notochord formation in mouse development Ang, SL, Rossant, J	Cell	1994
23383217	Foxa1 and Foxa2 are required for formation of the intervertebral discs Maier, JA, Lo, Y, Harfe, BD	PLoS One	2013
23213408	Foxa2 mediates critical functions of prechordal plate in patterning and morphogenesis and is cell autonomously required for early ventral endoderm morphogenesis Harrelson, Z, Kaestner, KH, Evans, SM	Biol Open	2012
12835403	Distinct regulators of Shh transcription in the floor plate and notochord indicate separate origins for these tissues in the mouse node Jeong, Y, Epstein, DJ	Development	2003
7916661	Sonic hedgehog, a member of a family of putative signaling molecules, is implicated in the regulation of CNS polarity Echelard, Y, Epstein, DJ, St-Jacques, B, Shen, L, Mohler, J, McMahon, JA, McMahon, AP	Cell	1993
31685615	SHH signaling mediated by a prechordal and brain enhancer controls forebrain organization Sagai, T, Amano, T, Maeno, A, Ajima, R, Shiroishi, T	Proc Natl Acad Sci U S A	2019
34672258	Ciliary Hedgehog signaling regulates cell survival to build the facial midline Abrams, SR, Reiter, JF	Elife	2021

Participants

Input

Shh gene [nucleoplasm] (Mus musculus)

Output

Shh(25-437) [endoplasmic reticulum lumen] (Mus musculus)

This event is regulated

Positively by

Regulator

Foxa1 [nucleoplasm] (Mus musculus)

Regulator

Foxa2 [nucleoplasm] (Mus musculus)

Orthologous Events

Expression of SHH in axial mesoderm (Homo sapiens)

Authored

May, B (2022-08-18)

Reviewed

Sasaki, H (2022-10-15)

Created

May, B (2022-08-27)

Cite Us!