Hira and Npm2 assemble H3.3-containing nucleosomes on paternal DNA

Stable Identifier
R-MMU-9822208
Type
Reaction [omitted]
Species
Mus musculus
Compartment
ReviewStatus
5/5
General
SVG |   | PPTX  | SBGN
Hira and Npm2 assemble H3.3-containing nucleosomes on paternal DNA
Hira mediates incorporation of the histone H3 variant H3.3 into newly formed chromatin in the male pronucleus and Hira (Lin et al. 2014) and H3.3 (Wen et al. 2014, Kong et al. 2018) are required for further development of the zygote. Deposition of oocyte-specific H1.8 (H1foo) onto the paternal genome begins within 5 minutes after fertilization (Gao et al. 2004). H1.8 is maximally localized in nuclei at the 1-cell stage and declines so that it is absent by the blastocyst stage (Funaya et al. 2018). The H2A variant H2ax (H2a.x) is present in the female pronucleus and is deposited in newly formed nucleosomes in the male pronucleus (Nashun et al. 2010).
Literature References
PubMed ID Title Journal Year
20943707 Changes in the nuclear deposition of histone H2A variants during pre-implantation development in mice

Akiyama, T, Nashun, B, Liu, H, Yukawa, M, Aoki, F

Development 2010
25087892 Hira-mediated H3.3 incorporation is required for DNA replication and ribosomal RNA transcription in the mouse zygote

Conti, M, Wong, P, Ramalho-Santos, M, Lin, CJ, Koh, FM

Dev Cell 2014
32169215 Initiation of Parental Genome Reprogramming in Fertilized Oocyte by Splicing Kinase SRPK1-Catalyzed Protamine Phosphorylation

Gou, LT, Adams, JA, Zhao, J, Lim, DH, Li, H, Meng, F, Hao, Y, Rosenfeld, MG, Li, D, Ma, W, Liang, Z, Fu, XD, Liu, MF, Shao, C, Zhang, X, Wang, X, Aubol, BE, Mellon, PL, Xu, R, Zhang, X

Cell 2020
29358330 Histone variant H3.3-mediated chromatin remodeling is essential for paternal genome activation in mouse preimplantation embryos

Liu, Z, Zhang, H, O'Neill, CL, Allis, CD, Rafii, S, Kong, Q, Palermo, GD, Shido, K, Zhang, J, Zhang, X, Rosenwaks, Z, Geng, F, Yan, P, Wen, D, Banaszynski, LA

J Biol Chem 2018
29963710 Linker histone H1FOO regulates the chromatin structure in mouse zygotes

Suzuki, MG, Funaya, S, Ooga, M, Aoki, F

FEBS Lett 2018
14729478 Rapid H1 linker histone transitions following fertilization or somatic cell nuclear transfer: evidence for a uniform developmental program in mice

Latham, KE, King, GJ, Parseghian, MH, Chung, YG, Adashi, EY, Gao, S

Dev Biol 2004
24799717 Histone variant H3.3 is an essential maternal factor for oocyte reprogramming

Rafii, S, Noh, KM, Liu, Y, Rosenwaks, Z, Elemento, O, Geng, F, Wen, D, Banaszynski, LA, Allis, CD, Xiang, J

Proc Natl Acad Sci U S A 2014
Participants
Catalyst Activity

histone chaperone activity of Hira:Npm2:dsDNA [nucleoplasm]

Orthologous Events
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