Interaction of Erp57 with MHC class I HC

Stable Identifier
R-MMU-983160
Type
Reaction [binding]
Species
Mus musculus
Compartment
General
SVG |   | PPTX  | SBGN
Interaction of Erp57 with MHC class I HC

Endoplasmic reticulum resident protein 57 (ERp57), is a member of the protein disulphide isomerase (PDI) family of thiol oxidoreducatases. It associates with Calnexin (CNX), and its soluble homolog calreticulin (CRT) and is recruited to MHC Class I Heavy Chain (HC). ERp57 is involved in the formation of HC disulphide bonds.

Literature References
PubMed ID Title Journal Year
16567808 Functions of ERp57 in the folding and assembly of major histocompatibility complex class I molecules

Zhang, Y, Baig, E, Williams, DB

J Biol Chem 2006
19196713 ERp57 does not require interactions with calnexin and calreticulin to promote assembly of class I histocompatibility molecules, and it enhances peptide loading independently of its redox activity

Zhang, Y, Kozlov, G, Pocanschi, CL, Brockmeier, U, Ireland, BS, Maattanen, P, Howe, C, Elliott, T, Gehring, K, Williams, DB

J Biol Chem 2009
Participants
Orthologous Events
Authored
Reviewed
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