Reactome | Alkal2 [extracellular region]

Alkal2 [extracellular region]

Stable Identifier

R-MMU-9842575

Type

Protein [EntityWithAccessionedSequence]

Species

Mus musculus

Compartment

extracellular region

Synonyms

HC-ALKAL2, Q80UG6

Locations in the PathwayBrowser

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Signal Transduction (Mus musculus)

- Signaling by Receptor Tyrosine Kinases (Mus musculus)
  - Signaling by ALK (Mus musculus)
    - ALK autophosphorylation (Mus musculus)
      - ALK dimer:ligand:type I ALK binding TKI [plasma membrane] (Mus musculus)
        
        ligand-bound ALK dimer [plasma membrane] (Mus musculus)
        
        ALK dimer:ALKAL2:(ALKAL1) [plasma membrane] (Mus musculus)
        
        ALKAL2:(ALKAL1) [extracellular region] (Mus musculus)
        
        ALKAL2 dimer [extracellular region] (Mus musculus)
        
        Alkal2 [extracellular region] (Mus musculus)
      - Active ALK dimer [plasma membrane] (Mus musculus)
        
        p-7Y ALK dimer:ALKAL2:(ALKAL1) [plasma membrane] (Mus musculus)
        
        ALKAL2:(ALKAL1) [extracellular region] (Mus musculus)
        
        ALKAL2 dimer [extracellular region] (Mus musculus)
        
        Alkal2 [extracellular region] (Mus musculus)
      - ligand-bound ALK dimer [plasma membrane] (Mus musculus)
        
        ALK dimer:ALKAL2:(ALKAL1) [plasma membrane] (Mus musculus)
        
        ALKAL2:(ALKAL1) [extracellular region] (Mus musculus)
        
        ALKAL2 dimer [extracellular region] (Mus musculus)
        
        Alkal2 [extracellular region] (Mus musculus)
    - ALK binds ALKAL ligand (Mus musculus)
      - ALK dimer:ALKAL2:(ALKAL1) [plasma membrane] (Mus musculus)
        
        ALKAL2:(ALKAL1) [extracellular region] (Mus musculus)
        
        ALKAL2 dimer [extracellular region] (Mus musculus)
        
        Alkal2 [extracellular region] (Mus musculus)
      - ALKAL2:(ALKAL1) [extracellular region] (Mus musculus)
        
        ALKAL2 dimer [extracellular region] (Mus musculus)
        
        Alkal2 [extracellular region] (Mus musculus)
    - Active ALK binds JAK3 (Mus musculus)
      - Active ALK dimer [plasma membrane] (Mus musculus)
        
        p-7Y ALK dimer:ALKAL2:(ALKAL1) [plasma membrane] (Mus musculus)
        
        ALKAL2:(ALKAL1) [extracellular region] (Mus musculus)
        
        ALKAL2 dimer [extracellular region] (Mus musculus)
        
        Alkal2 [extracellular region] (Mus musculus)
      - Active ALK:JAK3 [plasma membrane] (Mus musculus)
        
        Active ALK dimer [plasma membrane] (Mus musculus)
        
        p-7Y ALK dimer:ALKAL2:(ALKAL1) [plasma membrane] (Mus musculus)
        
        ALKAL2:(ALKAL1) [extracellular region] (Mus musculus)
        
        ALKAL2 dimer [extracellular region] (Mus musculus)
        
        Alkal2 [extracellular region] (Mus musculus)
    - Active ALK binds PLCG1 (Mus musculus)
      - Active ALK dimer [plasma membrane] (Mus musculus)
        
        p-7Y ALK dimer:ALKAL2:(ALKAL1) [plasma membrane] (Mus musculus)
        
        ALKAL2:(ALKAL1) [extracellular region] (Mus musculus)
        
        ALKAL2 dimer [extracellular region] (Mus musculus)
        
        Alkal2 [extracellular region] (Mus musculus)
      - Active ALK:PLCG1 [plasma membrane] (Mus musculus)
        
        Active ALK dimer [plasma membrane] (Mus musculus)
        
        p-7Y ALK dimer:ALKAL2:(ALKAL1) [plasma membrane] (Mus musculus)
        
        ALKAL2:(ALKAL1) [extracellular region] (Mus musculus)
        
        ALKAL2 dimer [extracellular region] (Mus musculus)
        
        Alkal2 [extracellular region] (Mus musculus)
    - Active ALK binds SHC1 (Mus musculus)
      - Active ALK dimer [plasma membrane] (Mus musculus)
        
        p-7Y ALK dimer:ALKAL2:(ALKAL1) [plasma membrane] (Mus musculus)
        
        ALKAL2:(ALKAL1) [extracellular region] (Mus musculus)
        
        ALKAL2 dimer [extracellular region] (Mus musculus)
        
        Alkal2 [extracellular region] (Mus musculus)
      - Active ALK:SHC1 [plasma membrane] (Mus musculus)
        
        Active ALK dimer [plasma membrane] (Mus musculus)
        
        p-7Y ALK dimer:ALKAL2:(ALKAL1) [plasma membrane] (Mus musculus)
        
        ALKAL2:(ALKAL1) [extracellular region] (Mus musculus)
        
        ALKAL2 dimer [extracellular region] (Mus musculus)
        
        Alkal2 [extracellular region] (Mus musculus)
    - Active ALK dimer binds IRS1 (Mus musculus)
      - Active ALK dimer [plasma membrane] (Mus musculus)
        
        p-7Y ALK dimer:ALKAL2:(ALKAL1) [plasma membrane] (Mus musculus)
        
        ALKAL2:(ALKAL1) [extracellular region] (Mus musculus)
        
        ALKAL2 dimer [extracellular region] (Mus musculus)
        
        Alkal2 [extracellular region] (Mus musculus)
      - Active ALK:IRS1 [plasma membrane] (Mus musculus)
        
        Active ALK dimer [plasma membrane] (Mus musculus)
        
        p-7Y ALK dimer:ALKAL2:(ALKAL1) [plasma membrane] (Mus musculus)
        
        ALKAL2:(ALKAL1) [extracellular region] (Mus musculus)
        
        ALKAL2 dimer [extracellular region] (Mus musculus)
        
        Alkal2 [extracellular region] (Mus musculus)
    - Active ALK phosphorylates IRS1 (Mus musculus)
      - Active ALK:IRS1 [plasma membrane] (Mus musculus)
        
        Active ALK dimer [plasma membrane] (Mus musculus)
        
        p-7Y ALK dimer:ALKAL2:(ALKAL1) [plasma membrane] (Mus musculus)
        
        ALKAL2:(ALKAL1) [extracellular region] (Mus musculus)
        
        ALKAL2 dimer [extracellular region] (Mus musculus)
        
        Alkal2 [extracellular region] (Mus musculus)
      - Active ALK:pY-IRS1 [plasma membrane] (Mus musculus)
        
        Active ALK dimer [plasma membrane] (Mus musculus)
        
        p-7Y ALK dimer:ALKAL2:(ALKAL1) [plasma membrane] (Mus musculus)
        
        ALKAL2:(ALKAL1) [extracellular region] (Mus musculus)
        
        ALKAL2 dimer [extracellular region] (Mus musculus)
        
        Alkal2 [extracellular region] (Mus musculus)
    - Active ALK phosphorylates JAK3 (Mus musculus)
      - Active ALK:JAK3 [plasma membrane] (Mus musculus)
        
        Active ALK dimer [plasma membrane] (Mus musculus)
        
        p-7Y ALK dimer:ALKAL2:(ALKAL1) [plasma membrane] (Mus musculus)
        
        ALKAL2:(ALKAL1) [extracellular region] (Mus musculus)
        
        ALKAL2 dimer [extracellular region] (Mus musculus)
        
        Alkal2 [extracellular region] (Mus musculus)
      - Active ALK:p-Y980 JAK3 [plasma membrane] (Mus musculus)
        
        Active ALK dimer [plasma membrane] (Mus musculus)
        
        p-7Y ALK dimer:ALKAL2:(ALKAL1) [plasma membrane] (Mus musculus)
        
        ALKAL2:(ALKAL1) [extracellular region] (Mus musculus)
        
        ALKAL2 dimer [extracellular region] (Mus musculus)
        
        Alkal2 [extracellular region] (Mus musculus)
    - Active ALK phosphorylates PLCG1 (Mus musculus)
      - Active ALK:PLCG1 [plasma membrane] (Mus musculus)
        
        Active ALK dimer [plasma membrane] (Mus musculus)
        
        p-7Y ALK dimer:ALKAL2:(ALKAL1) [plasma membrane] (Mus musculus)
        
        ALKAL2:(ALKAL1) [extracellular region] (Mus musculus)
        
        ALKAL2 dimer [extracellular region] (Mus musculus)
        
        Alkal2 [extracellular region] (Mus musculus)
      - Active ALK:p-4Y PLCG1 [plasma membrane] (Mus musculus)
        
        Active ALK dimer [plasma membrane] (Mus musculus)
        
        p-7Y ALK dimer:ALKAL2:(ALKAL1) [plasma membrane] (Mus musculus)
        
        ALKAL2:(ALKAL1) [extracellular region] (Mus musculus)
        
        ALKAL2 dimer [extracellular region] (Mus musculus)
        
        Alkal2 [extracellular region] (Mus musculus)
    - Active ALK phosphorylates SHC1 (Mus musculus)
      - Active ALK:SHC1 [plasma membrane] (Mus musculus)
        
        Active ALK dimer [plasma membrane] (Mus musculus)
        
        p-7Y ALK dimer:ALKAL2:(ALKAL1) [plasma membrane] (Mus musculus)
        
        ALKAL2:(ALKAL1) [extracellular region] (Mus musculus)
        
        ALKAL2 dimer [extracellular region] (Mus musculus)
        
        Alkal2 [extracellular region] (Mus musculus)
      - Active ALK:p-3Y SHC1 [plasma membrane] (Mus musculus)
        
        Active ALK dimer [plasma membrane] (Mus musculus)
        
        p-7Y ALK dimer:ALKAL2:(ALKAL1) [plasma membrane] (Mus musculus)
        
        ALKAL2:(ALKAL1) [extracellular region] (Mus musculus)
        
        ALKAL2 dimer [extracellular region] (Mus musculus)
        
        Alkal2 [extracellular region] (Mus musculus)
    - Active ALK recruits PI3K (Mus musculus)
      - Active ALK dimer [plasma membrane] (Mus musculus)
        
        p-7Y ALK dimer:ALKAL2:(ALKAL1) [plasma membrane] (Mus musculus)
        
        ALKAL2:(ALKAL1) [extracellular region] (Mus musculus)
        
        ALKAL2 dimer [extracellular region] (Mus musculus)
        
        Alkal2 [extracellular region] (Mus musculus)
      - Active ALK:PI3K [plasma membrane] (Mus musculus)
        
        Active ALK dimer [plasma membrane] (Mus musculus)
        
        p-7Y ALK dimer:ALKAL2:(ALKAL1) [plasma membrane] (Mus musculus)
        
        ALKAL2:(ALKAL1) [extracellular region] (Mus musculus)
        
        ALKAL2 dimer [extracellular region] (Mus musculus)
        
        Alkal2 [extracellular region] (Mus musculus)
    - Liganded-ALK dimer binds type I ALK-binding TKIs (Mus musculus)
      - ALK dimer:ligand:type I ALK binding TKI [plasma membrane] (Mus musculus)
        
        ligand-bound ALK dimer [plasma membrane] (Mus musculus)
        
        ALK dimer:ALKAL2:(ALKAL1) [plasma membrane] (Mus musculus)
        
        ALKAL2:(ALKAL1) [extracellular region] (Mus musculus)
        
        ALKAL2 dimer [extracellular region] (Mus musculus)
        
        Alkal2 [extracellular region] (Mus musculus)
      - ligand-bound ALK dimer [plasma membrane] (Mus musculus)
        
        ALK dimer:ALKAL2:(ALKAL1) [plasma membrane] (Mus musculus)
        
        ALKAL2:(ALKAL1) [extracellular region] (Mus musculus)
        
        ALKAL2 dimer [extracellular region] (Mus musculus)
        
        Alkal2 [extracellular region] (Mus musculus)
    - PI3K synthesizes PIP3 downstream of ALK (Mus musculus)
      - Active ALK:PI3K [plasma membrane] (Mus musculus)
        
        Active ALK dimer [plasma membrane] (Mus musculus)
        
        p-7Y ALK dimer:ALKAL2:(ALKAL1) [plasma membrane] (Mus musculus)
        
        ALKAL2:(ALKAL1) [extracellular region] (Mus musculus)
        
        ALKAL2 dimer [extracellular region] (Mus musculus)
        
        Alkal2 [extracellular region] (Mus musculus)
    - PTPN6 dephosphorylates JAK3 (Mus musculus)
      - Active ALK:JAK3 [plasma membrane] (Mus musculus)
        
        Active ALK dimer [plasma membrane] (Mus musculus)
        
        p-7Y ALK dimer:ALKAL2:(ALKAL1) [plasma membrane] (Mus musculus)
        
        ALKAL2:(ALKAL1) [extracellular region] (Mus musculus)
        
        ALKAL2 dimer [extracellular region] (Mus musculus)
        
        Alkal2 [extracellular region] (Mus musculus)
      - Active ALK:p-Y980 JAK3 [plasma membrane] (Mus musculus)
        
        Active ALK dimer [plasma membrane] (Mus musculus)
        
        p-7Y ALK dimer:ALKAL2:(ALKAL1) [plasma membrane] (Mus musculus)
        
        ALKAL2:(ALKAL1) [extracellular region] (Mus musculus)
        
        ALKAL2 dimer [extracellular region] (Mus musculus)
        
        Alkal2 [extracellular region] (Mus musculus)
    - STAT3 is phosphorylated downstream of active ALK (Mus musculus)
      - Active ALK dimer [plasma membrane] (Mus musculus)
        
        p-7Y ALK dimer:ALKAL2:(ALKAL1) [plasma membrane] (Mus musculus)
        
        ALKAL2:(ALKAL1) [extracellular region] (Mus musculus)
        
        ALKAL2 dimer [extracellular region] (Mus musculus)
        
        Alkal2 [extracellular region] (Mus musculus)

External Reference Information

External Reference

UniProt:Q80UG6

Gene Names

Alkal2

Reference Genes

BioGPS Gene:100294583 Alkal2

ENSEMBL:ENSMUSG00000054204

ENSEMBL:ENSMUSG00000054204.7 Alkal2

KEGG Gene (Mus musculus):100294583 Alkal2

Monarch:100294583 Alkal2

NCBI Gene:100294583 Alkal2

UCSC:Q80UG6 Alkal2

Reference Transcript

RefSeq:NM_001159743.1 Alkal2

Other Identifiers

100294583

10395136

138215_r_at

17274744

4413608

4414122

4989261

5009160

5107289

5107520

5253899

5380879

GO:0005125

GO:0005575

GO:0005576

GO:0005615

GO:0005886

GO:0007169

GO:0010976

GO:0016020

GO:0023052

GO:0030154

GO:0030297

GO:0030298

GO:0030971

GO:0048018

GO:0048856

GO:0070374

GO:0070378

GO:0098772

ILMN_2523016

mMC017222

Participates

as a component of

ALKAL2 dimer [extracellular region] (Mus musculus)

Other forms of this molecule

Alkal2 [extracellular region]

Inferred From

HC-ALKAL2 [extracellular region] (Homo sapiens)

Modified Residues

Name

Inter-chain Crosslink via L-cystine (cross-link) at 66 and 66 (in Homo sapiens)

Coordinate

PsiMod Name

L-cystine (cross-link)

PsiMod Definition

A protein modification that effectively cross-links two L-cysteine residues to form L-cystine.

Cross References

RefSeq

NP_001153215.1

Ensembl

ENSMUSP00000070037, ENSMUSG00000054204, ENSMUST00000067087

PRO

Q80UG6

MGI

3697448

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