Ebf2 binds Blnc1

Stable Identifier
R-MMU-9844361
Type
Reaction [binding]
Species
Mus musculus
Compartment
nucleoplasm
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Ebf2 binds Blnc1
Mouse lncRNA named Blnc1 (for Brown fat lncRNA 1) is a nuclear lncRNA that was found to promote mouse brown and beige adipocyte differentiation and function. Blnc1 lncRNA forms a complex with the transcription factor Ebf2 in mouse adipocytes and stimulates Ebf2-mediated activation of thermogenic genes, such as Ucp1. Blnc1 lncRNA gene also possesses an Ebf-binding site in its promoter, and its expression is positively regulated by Ebf2, thus creating a positive feedback loop (Zhao et al. 2014). Hnrnpu (heterogeneous nuclear ribonucleoprotein U) facilitates the interaction between Blnc1 lncRNA and Ebf2 in mouse adipocytes by directly participating in the formation of the Ebf2 ribonucleoprotein complex (Mi et al. 2017).
Literature References
PubMed ID Title Journal Year
25002143 A long noncoding RNA transcriptional regulatory circuit drives thermogenic adipocyte differentiation

Yu, Q, Zhao, XY, Wang, GX, Li, S, Lin, JD

Mol Cell 2014
28123941 Conserved function of the long noncoding RNA Blnc1 in brown adipocyte differentiation

Zhao, XY, Li, S, Mi, L, Yang, G, Lin, JD

Mol Metab 2017
Participants
Input
Output
Orthologous Events
EBF2 binds Blnc1 lncRNA (Homo sapiens)
Authored
Orlic-Milacic, M  (2023-09-25)
Reviewed
Chun, TH  (2023-11-29)
Created
Orlic-Milacic, M  (2023-09-15)
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