CK2alpha phosphorylates Bmal1 (Arntl) on serine-97

Stable Identifier
R-MMU-9912393
Type
Reaction [transition]
Species
Mus musculus
Compartment
cytosol
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
CK2alpha phosphorylates Bmal1 (Arntl) on serine-97
CK2alpha, the catalytic subunit of casein kinase II (CK2) phosphorylates Bmal1 (Arntl) on serine-97, serine-90 of non-canonical isoforms (Tamaru et al. 2009). The phosphorylation enhances the nuclear accumulation of Arntl (Tamaru et al. 2009). Cry1 mediates the interaction of CK2beta, the regulatory subunit of CK2, with Bmal1, inhibiting the phosphorylation of Bmal1 by CK2alpha (Tamaru et al. 2015).
Literature References
PubMed ID Title Journal Year
26562092 CRY Drives Cyclic CK2-Mediated BMAL1 Phosphorylation to Control the Mammalian Circadian Clock

Nakahata, Y, Hattori, M, Takamatsu, K, Sassone-Corsi, P, Ozawa, T, Honda, K, van der Horst, GT, Tamaru, T

PLoS Biol 2015
19330005 CK2alpha phosphorylates BMAL1 to regulate the mammalian clock

Hirayama, J, Nagai, K, Isojima, Y, Tamaru, T, Takamatsu, K, Sassone-Corsi, P, Norioka, S

Nat Struct Mol Biol 2009
Participants
Input
Output
Catalyst Activity

protein serine/threonine kinase activity of CK2alpha [cytosol]

Physical Entity
CK2alpha [cytosol] (Mus musculus)
Activity
protein serine/threonine kinase activity (GO:0004674)
This event is regulated
Negatively by
Regulator
Csnk2b [nucleoplasm] (Mus musculus)
Orthologous Events
CK2alpha phosphorylates BMAL1 (ARNTL) on serine-90 (Homo sapiens)
Authored
May, B  (2024-06-01)
Reviewed
Sancar, A  (2025-02-14)
Albrecht, U  (2025-02-18)
Created
May, B  (2024-06-08)
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