Reactome | Adrm1 [nucleoplasm]

Adrm1 [nucleoplasm]

Stable Identifier

R-MMU-9918361

Type

Protein [EntityWithAccessionedSequence]

Species

Mus musculus

Compartment

nucleoplasm

Synonyms

ADRM1, Q9JKV1

Locations in the PathwayBrowser

Expand all

Cell Cycle (Mus musculus)

- Cell Cycle Checkpoints (Mus musculus)
  - G1/S DNA Damage Checkpoints (Mus musculus)
    - p53-Independent G1/S DNA Damage Checkpoint (Mus musculus)
      - Ubiquitin-Mediated Degradation of Phosphorylated Cdc25A (Mus musculus)
        
        Proteolytic degradation of ubiquitinated-Cdc25A (Mus musculus)
        
        26S proteasome [nucleoplasm] (Mus musculus)
        
        19S regulatory particle [nucleoplasm] (Mus musculus)
        
        19S RP base [nucleoplasm] (Mus musculus)
        
        Adrm1 [nucleoplasm] (Mus musculus)
- Cell Cycle, Mitotic (Mus musculus)
  - Mitotic G1 phase and G1/S transition (Mus musculus)
    - G1/S Transition (Mus musculus)
      - Cyclin E associated events during G1/S transition (Mus musculus)
        
        SCF(Skp2)-mediated degradation of p27/p21 (Mus musculus)
        
        Degradation of ubiquitinated p27/p21 by the 26S proteasome (Mus musculus)
        
        26S proteasome [nucleoplasm] (Mus musculus)
        
        19S regulatory particle [nucleoplasm] (Mus musculus)
        
        19S RP base [nucleoplasm] (Mus musculus)
        
        Adrm1 [nucleoplasm] (Mus musculus)
  - Regulation of mitotic cell cycle (Mus musculus)
    - APC/C-mediated degradation of cell cycle proteins (Mus musculus)
      - APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 (Mus musculus)
        
        APC/C:Cdh1-mediated degradation of Skp2 (Mus musculus)
        
        26S proteasome [nucleoplasm] (Mus musculus)
        
        19S regulatory particle [nucleoplasm] (Mus musculus)
        
        19S RP base [nucleoplasm] (Mus musculus)
        
        Adrm1 [nucleoplasm] (Mus musculus)
      - Autodegradation of Cdh1 by Cdh1:APC/C (Mus musculus)
        
        Degradation of multiubiquitinated Cdh1 (Mus musculus)
        
        26S proteasome [nucleoplasm] (Mus musculus)
        
        19S regulatory particle [nucleoplasm] (Mus musculus)
        
        19S RP base [nucleoplasm] (Mus musculus)
        
        Adrm1 [nucleoplasm] (Mus musculus)
  - S Phase (Mus musculus)
    - Cyclin A:Cdk2-associated events at S phase entry (Mus musculus)
      - SCF(Skp2)-mediated degradation of p27/p21 (Mus musculus)
        
        Degradation of ubiquitinated p27/p21 by the 26S proteasome (Mus musculus)
        
        26S proteasome [nucleoplasm] (Mus musculus)
        
        19S regulatory particle [nucleoplasm] (Mus musculus)
        
        19S RP base [nucleoplasm] (Mus musculus)
        
        Adrm1 [nucleoplasm] (Mus musculus)

Cellular responses to stimuli (Mus musculus)

- Cellular responses to stress (Mus musculus)
  - Cellular response to chemical stress (Mus musculus)
    - KEAP1-NFE2L2 pathway (Mus musculus)
      - Nuclear events mediated by NFE2L2 (Mus musculus)
        
        GSK3B and BTRC:CUL1-mediated-degradation of NFE2L2 (Mus musculus)
        
        Ub,pS335,S338,T NFE2L2 is degraded (Mus musculus)
        
        26S proteasome [nucleoplasm] (Mus musculus)
        
        19S regulatory particle [nucleoplasm] (Mus musculus)
        
        19S RP base [nucleoplasm] (Mus musculus)
        
        Adrm1 [nucleoplasm] (Mus musculus)

Gene expression (Transcription) (Mus musculus)

- RNA Polymerase II Transcription (Mus musculus)
  - Generic Transcription Pathway (Mus musculus)
    - Transcriptional regulation by RUNX2 (Mus musculus)
      - Regulation of RUNX2 expression and activity (Mus musculus)
        
        26S proteasome degrades PolyUb-RUNX2 (Mus musculus)
        
        26S proteasome [nucleoplasm] (Mus musculus)
        
        19S regulatory particle [nucleoplasm] (Mus musculus)
        
        19S RP base [nucleoplasm] (Mus musculus)
        
        Adrm1 [nucleoplasm] (Mus musculus)
    - Transcriptional regulation by RUNX3 (Mus musculus)
      - Regulation of RUNX3 expression and activity (Mus musculus)
        
        Polyubiquitinated RUNX3 is degraded by the proteasome (Mus musculus)
        
        26S proteasome [nucleoplasm] (Mus musculus)
        
        19S regulatory particle [nucleoplasm] (Mus musculus)
        
        19S RP base [nucleoplasm] (Mus musculus)
        
        Adrm1 [nucleoplasm] (Mus musculus)

External Reference Information

External Reference

UniProt:Q9JKV1

Gene Names

Adrm1

Reference Genes

BioGPS Gene:56436 Adrm1

ENSEMBL:ENSMUSG00000039041

KEGG:mmu:56436 Adrm1

Monarch:56436 Adrm1

NCBI Gene:56436 Adrm1

UCSC:Q9JKV1 Adrm1

Reference Transcript

RefSeq:NM_019822.3 Adrm1

Other Identifiers

10479351

10499883

1419263_a_at

1438170_x_at

17380729

17407396

4305412

4439511

4478685

4491917

4607460

4657481

4696367

4718540

4723145

4736085

4740539

4765179

4801528

4818600

4912399

4930945

4937955

4973148

5009068

5032211

5100264

5122983

5126392

5240815

5249135

5260279

5278246

5279676

5321950

5350107

5366720

5370218

5374580

5553081

5558766

5582301

56436

97875_at

A_51_P214631

A_52_P675072

A_55_P2092329

A_55_P2761985

GE42794

GO:0000502

GO:0001541

GO:0005515

GO:0005634

GO:0005737

GO:0007286

GO:0008541

GO:0022414

GO:0033081

GO:0042699

GO:0048477

GO:0048538

GO:0048856

GO:0060009

GO:0060399

GO:0060612

GO:0061133

GO:0070628

GO:0072520

GO:0098772

ILMN_2601590

aa271499_s_at

mMC025475

Participates

as a component of

19S RP base [nucleoplasm] (Mus musculus)

Other forms of this molecule

Adrm1 [cytosol]

Inferred From

ADRM1 [nucleoplasm] (Homo sapiens)

Cross References

RefSeq

NP_062796.2

ENSEMBL

ENSMUSG00000039041, ENSMUST00000061437, ENSMUSP00000050076

PRO

Q9JKV1

GlyGen

Q9JKV1

MGI

1929289

PDB

2Z59, 2R2Y

Interactors (2)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
IntAct:EBI-4399559 UBIQ			0.709	5
UniProt:Q99460-1 PSMD1			0.573	2

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