Clock acetylates Bmal1 on lysine-544 (lysine-537 of isoform 2)

Stable Identifier
R-MMU-9920709
Type
Reaction [transition]
Species
Mus musculus
Compartment
nucleoplasm
ReviewStatus
5/5
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Clock acetylates Bmal1 on lysine-544 (lysine-537 of isoform 2)
Clock in the Bmal1:Clock heterodimer acetylates lysine-544 of the canonical Bmal1 isoform (lysine-537 of isoform 2) (Hirayama et al. 2007). The acetylation reaction occurs at zeitgeber 15 (evening) at the time when transactivation by Bmal1:Clock declines (Hirayama et al. 2007). The acetylation is required for efficient interaction with the Cry:Per:kinase complex that represses Bmal1:Clock activity (Hirayama et al. 2007).
Literature References
PubMed ID Title Journal Year
18075593 CLOCK-mediated acetylation of BMAL1 controls circadian function

Hirayama, J, Sahar, S, Grimaldi, B, Tamaru, T, Takamatsu, K, Nakahata, Y, Sassone-Corsi, P

Nature 2007
Participants
Input
Output
Catalyst Activity

protein-lysine-acetyltransferase activity of p-S97-Bmal1:p-T451,T461,S440,S441,S446-Clock:Per2 gene [nucleoplasm]

Physical Entity
p-S97-Bmal1:p-T451,T461,S440,S441,S446-Clock:Per2 gene [nucleoplasm] (Mus musculus)
Activity
protein-lysine-acetyltransferase activity (GO:0061733)
Orthologous Events
CLOCK acetylates BMAL1 on lysine-538 (Homo sapiens)
Authored
May, B  (2024-08-15)
Reviewed
Sancar, A  (2025-02-14)
Albrecht, U  (2025-02-18)
Created
May, B  (2024-09-03)
Cite Us!