Reactome | phospho-Jak2 [cytosol]

phospho-Jak2 [cytosol]

Stable Identifier

R-MMU-997248

Type

Protein [EntityWithAccessionedSequence]

Species

Mus musculus

Compartment

cytosol

Synonyms

p-Y813-JAK2, Q62120

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:Q62120 Jak2

Gene Names

Jak2

Chain

chain:1-1129

Reference Genes

BioGPS Gene:16452 Jak2

KEGG Gene (Mus musculus):16452 Jak2

Monarch:16452 Jak2

NCBI Gene:16452 Jak2

Reference Transcript

Participant Of

input

SH2B proteins bind JAK2

hasComponent

SH2B family:p-Y813-JAK2 [cytosol]

Other forms of this molecule

phospho-Jak2 [cytosol]

Jak2 [cytosol]

phospho-Jak2 [cytosol]

p-12Y-Jak2 [cytosol]

p-Y1007-Jak2 [cytosol]

Jak2 [endosome lumen]

phospho-Jak2 [cytosol]

p-Jak2 [cytosol]

Inferred From

p-Y813-JAK2 [cytosol] (Homo sapiens)

Modified Residues

Name

O4'-phospho-L-tyrosine at 813

Coordinate

813

PsiMod Name

O4'-phospho-L-tyrosine [MOD:00048]

PsiMod Definition

A protein modification that effectively converts an L-tyrosine residue to O4'-phospho-L-tyrosine.

Cross References

RefSeq

NP_001041642.1, NP_032439.2

ZINC - World Drugs

JAK2_MOUSE

ZINC - FDA approved

JAK2_MOUSE

ZINC - Substances

JAK2_MOUSE

ZINC target

Q62120

PRO

Q62120

MGI

96629

ZINC - Predictions - Purchasable

JAK2_MOUSE

PDB

4GL9, 2HDX

Interactors (7)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q91ZM2 Sh2b1	2	Sh2b1 [cytosol] (R-MMU-1675482) Sh2b1 [cytosol] (R-MMU-2671856)	0.667	3
UniProt:P46527 CDKN1B	8	CDKN1B [nucleoplasm] (R-HSA-182563) p-Y88-CDKN1B [nucleoplasm] (R-HSA-8942808) p-Y88-CDKN1B [cytosol] (R-HSA-8848438) CDKN1B [cytosol] (R-HSA-198622) p-T187-CDKN1B [nucleoplasm] (R-HSA-187525) p-T157-CDKN1B [cytosol] (R-HSA-198629) p-S10 CDKN1B [nucleoplasm] (R-HSA-9632832) p-S10 CDKN1B [cytosol] (R-HSA-9632829)	0.626	7
UniProt:P14753 Epor	3	p-8Y-Epor [plasma membrane] (R-MMU-9006275) EpoR [plasma membrane] (R-MMU-206154) phospho-Epor [plasma membrane] (R-MMU-9006274)	0.589	4
UniProt:P48356 Lepr			0.524	3
UniProt:Q5VWK5 IL23R	2	IL23R [plasma membrane] (R-HSA-447156) p-Y-IL23R [plasma membrane] (R-HSA-8950616)	0.499	2
UniProt:O35716 Socs1	2	Socs1 [cytosol] (R-MMU-204910) Socs1 [cytosol] (R-MMU-912674)	0.482	2
UniProt:P10686 Plcg1	8	phospho-Plcg1 [plasma membrane] (R-RNO-1169084) p-4Y-Plcg1 [plasma membrane] (R-RNO-9034825) Plcg1 [plasma membrane] (R-RNO-182093) Plcg1 [plasma membrane] (R-RNO-167682) p-Plcg1 [plasma membrane] (R-RNO-182042) Plcg1 [cytosol] (R-RNO-202320) phospho-Plcg1 [cytosol] (R-RNO-202357) phospho-Plcg1 [plasma membrane] (R-RNO-167679)	0.463	3

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