Trehalose-6-phosphate is hydrolyzed to trehalose

Stable Identifier
R-MTU-868608
Type
Reaction [transition]
Species
Mycobacterium tuberculosis
Compartment
cytosol
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Trehalose-6-phosphate is hydrolyzed to trehalose
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Hydrolysis of trehalose phosphate, catalyzed by OtsB2, gives trehalose. The enzyme needs magnesium for its activity. A second homologue, OtsB1 is non-functional (De Smet et al, 2000; Edavana et al, 2004).
Literature References
PubMed ID Title Journal Year
10658666 Three pathways for trehalose biosynthesis in mycobacteria

De Smet, KA, Weston, A, Brown, IN, Young, DB, Robertson, BD

Microbiology 2000
15158675 Cloning and expression of the trehalose-phosphate phosphatase of Mycobacterium tuberculosis: comparison to the enzyme from Mycobacterium smegmatis

Edavana, VK, Pastuszak, I, Carroll, JD, Thampi, P, Abraham, EC, Elbein, AD

Arch Biochem Biophys 2004
Participants
Input
Output
Participates
as an event of
Catalyst Activity

trehalose-phosphatase activity of OtsB-Mg2+ [cytosol]

Physical Entity
OtsB-Mg2+ [cytosol] (Mycobacterium tuberculosis)
Activity
trehalose-phosphatase activity (GO:0004805)
Authored
Stephan, R  (2010-05-29)
Reviewed
Warner, D  (2010-11-25)
Created
Stephan, R  (2010-06-02)
Cite Us!