mycothiol binds formaldehyde and is dehydrogenated

Stable Identifier
R-MTU-879245
Type
Reaction [transition]
Species
Mycobacterium tuberculosis
Compartment
cytosol
ReviewStatus
5/5
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mycothiol binds formaldehyde and is dehydrogenated
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In the detoxification of formaldehyde, mycothiol first binds to the molecule forming a hydroxymethyl adduct intermediate (M-S-CH2OH, not shown), which is dehydrogenated by the bifunctional MscR enzyme to formylmycothiol (Vogt et al, 2003).
Literature References
PubMed ID Title Journal Year
12809551 The metabolism of nitrosothiols in the Mycobacteria: identification and characterization of S-nitrosomycothiol reductase

Vogt, RN, Steenkamp, DJ, Zheng, R, Blanchard, JS

Biochem J 2003
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Catalyst Activity

mycothiol-dependent formaldehyde dehydrogenase activity of MscR:Zn2+ [cytosol]

Physical Entity
MscR:Zn2+ [cytosol] (Mycobacterium tuberculosis)
Activity
mycothiol-dependent formaldehyde dehydrogenase activity (GO:0050607)
Authored
Stephan, R  (2010-06-15)
Reviewed
Warner, D  (2010-11-25)
Created
Stephan, R  (2010-06-16)
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