mycothiol S-conjugate is cleaved into mercapturic acid and GlcN-Ins

Stable Identifier
R-MTU-879311
Type
Reaction [transition]
Species
Mycobacterium tuberculosis
Compartment
cytosol
ReviewStatus
5/5
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mycothiol S-conjugate is cleaved into mercapturic acid and GlcN-Ins
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The hydrolysis of the mycothiol S-conjugate, catalyzed by the Mca amidase, results in a so called mercapturic acid (acetylcysteine adduct) of the toxin, and glucosaminyl-inositol which is recycled to mycothiol (Steffek et al, 2003).
Literature References
PubMed ID Title Journal Year
14556638 Characterization of Mycobacterium tuberculosis mycothiol S-conjugate amidase

Steffek, M, Newton, GL, Av-Gay, Y, Fahey, RC

Biochemistry 2003
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Catalyst Activity

hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides of mca:Zn2+ [cytosol]

Physical Entity
mca:Zn2+ [cytosol] (Mycobacterium tuberculosis)
Activity
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides (GO:0016811)
Authored
Stephan, R  (2010-06-15)
Reviewed
Warner, D  (2010-11-25)
Created
Stephan, R  (2010-06-16)
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