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Sulfate assimilation
Stable Identifier
R-MTU-936635
Type
Pathway
Species
Mycobacterium tuberculosis
ReviewStatus
5/5
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Mycobacterium tuberculosis biological processes (Mycobacterium tuberculosis)
Sulfur compound metabolism (Mycobacterium tuberculosis)
Sulfate assimilation (Mycobacterium tuberculosis)
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Uptake of sulfur in
Mycobacterium tuberculosis
happens exclusively through sulfate assimiliation, an abundant molecule in the bacterium's environment. All enzymes participating in this process are non-redundant ie they are essential enzymes. Sulfate is first taken up via an ABC transporter and appended to AMP giving APS and PAPS, which can be considered the activated forms of sulfate and are used in cysteine and sulfolipid biosynthesis (Bhave et al, 2007).
Literature References
PubMed ID
Title
Journal
Year
17970225
Drug targets in mycobacterial sulfur metabolism
Carroll, KS
,
Bhave, DP
,
Muse WB, 3rd
Infect Disord Drug Targets
2007
Participants
Events
sulfate binds to SubI outside the membrane
(Mycobacterium tuberculosis)
sulfate uptake in the cytosol
(Mycobacterium tuberculosis)
sulfate is activated to APS
(Mycobacterium tuberculosis)
APS is phosphorylated to PAPS
(Mycobacterium tuberculosis)
PAPS is dephosphorylated to APS
(Mycobacterium tuberculosis)
Participates
as an event of
Sulfur compound metabolism (Mycobacterium tuberculosis)
Event Information
Go Biological Process
sulfate assimilation (0000103)
Authored
Stephan, R (2010-06-17)
Reviewed
Warner, D (2010-11-25)
Created
Jassal, B (2010-08-24)
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