Reactome | deacetylation of O-acetylserine and sulfhydrylation using CysK2

deacetylation of O-acetylserine and sulfhydrylation using CysK2

Stable Identifier

R-MTU-936745

Type

Reaction [transition]

Species

Mycobacterium tuberculosis

Compartment

cytosol

ReviewStatus

5/5

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deacetylation of O-acetylserine and sulfhydrylation using CysK2

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Expression of the other enzyme catalyzing the sulfhydrylation of O-acetylserine, CysK2, is increased by oxidative stress (Mehra and Kaushal, 2009; Schnell et al, 2007).

Literature References

PubMed ID	Title	Journal	Year
17567578	Structural insights into catalysis and inhibition of O-acetylserine sulfhydrylase from Mycobacterium tuberculosis. Crystal structures of the enzyme alpha-aminoacrylate intermediate and an enzyme-inhibitor complex Oehlmann, W, Singh, M, Schneider, G, Schnell, R	J Biol Chem	2007
19376862	Functional genomics reveals extended roles of the Mycobacterium tuberculosis stress response factor sigmaH Mehra, S, Kaushal, D	J Bacteriol	2009

Participants

Input

Output

Participates

as an event of

Cysteine synthesis from O-acetylserine (Mycobacterium tuberculosis)

Catalyst Activity

cysteine synthase activity of PXLP-K65-CysK2 [cytosol]

Physical Entity

PXLP-K65-CysK2 [cytosol] (Mycobacterium tuberculosis)

Activity

cysteine synthase activity (GO:0004124)

Authored

Stephan, R (2010-06-21)

Reviewed

Warner, D (2010-11-25)

Created

Jassal, B (2010-08-24)

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