Cysteine from cystathionine and vice versa

Stable Identifier
R-MTU-937192
Type
Reaction [transition]
Species
Mycobacterium tuberculosis
Compartment
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The pyridoxalphosphate-dependent enzyme MetB not only catalyzes destruction of cystathonine to cysteine but also the transfer of homoserine onto cysteine to yield cystathione from O-succinyl-L-homoserine. This ensures that cysteine and methionine can be interconverted when the need arises. (Wheeler et al, 2005)

Literature References
PubMed ID Title Journal Year
15576367 Functional demonstration of reverse transsulfuration in the Mycobacterium tuberculosis complex reveals that methionine is the preferred sulfur source for pathogenic Mycobacteria

Wheeler, PR, Coldham, NG, Keating, L, Gordon, SV, Wooff, EE, Parish, T, Hewinson, RG

J Biol Chem 2005
Participants
Participant Of
Catalyst Activity
Catalyst Activity
Title
cystathionine gamma-lyase activity of PXLP-K208-MetB dimer [cytosol]
Physical Entity
Activity
Cross References
Target Pathogen
Authored
Reviewed
Created