Dephosphorylation of EPSP yields chorismate

Stable Identifier
R-MTU-964884
Type
Reaction [transition]
Species
Mycobacterium tuberculosis
Compartment
cytosol
ReviewStatus
5/5
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Dephosphorylation of EPSP yields chorismate
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AroF in complex with reduced FMN catalyzes the dehydration and phosphate cleavage of EPSP, yielding chorismate. The cofactor FMN is reduced by NADPH which makes the enzyme stable in aerobic conditions and is known from similar fungal enzymes (Ely et al, 2008).
Literature References
PubMed ID Title Journal Year
18445278 The Mycobacterium tuberculosis Rv2540c DNA sequence encodes a bifunctional chorismate synthase

Basso, LA, Santos, DS, Palma, MS, Frazzon, J, Nunes, JE, Ely, F, Schroeder, EK

BMC Biochem 2008
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Catalyst Activity

chorismate synthase activity of AroC-FMN [cytosol]

Physical Entity
AroC-FMN [cytosol] (Mycobacterium tuberculosis)
Activity
chorismate synthase activity (GO:0004107)
Authored
Stephan, R  (2010-09-13)
Reviewed
Warner, D  (2010-11-25)
Created
Jassal, B  (2010-09-20)
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